Ocean Thermal Energy Conversion (OTEC) using non-azeotropic mixtures such as ammonia/water as working fluid and the multistage cycle has been investigated in order to improve the thermal efficiency of the cycle because of small ocean temperature differences. The performance and effectiveness of the multistage cycle are barely understood. In addition, previous evaluation methods of heat exchange process cannot clearly indicate the influence of the thermophysical characteristics of the working fluid on the power output. Consequently, this study investigated the influence of reduction of the irreversible losses in the heat exchange process on the system performance in double-stage Rankine cycle using pure working fluid. Single Rankine, double-stage Rankine and Kalina cycles were analyzed to ascertain the system characteristics. The simple evaluation method of the temperature difference between the working fluid and the seawater is applied to this analysis. From the results of the parametric performance analysis it can be considered that double-stage Rankine cycle using pure working fluid can reduce the irreversible losses in the heat exchange process as with the Kalina cycle using an ammonia/water mixture. Considering the maximum power efficiency obtained in the study, double-stage Rankine and Kalina cycles can improve the power output by reducing the irreversible losses in the cycle.

Ocean thermal energy conversion (OTEC) harvests the power from the thermal energy in the ocean, which is reserved in the ocean as the temperature difference between warm surface and cold deep seawaters. In the energy conversion, the heat exchangers transfer the thermal energy to the heat engine, which converts it into power. The pressure drops yielded by piping, valve and heat exchangers cause pump loads, which show significant negative power with respect to net power in OTEC. The heat transfer performance and the pressure drop in heat exchanger depend on the types and shapes of each heat transfer area. Generally, heat exchangers with higher friction factors yield higher heat transfer performance and vice versa. However, heat transfer performance and pressure drop are separately evaluated and there is no comprehensive performance evaluation index for OTEC power take-off. Therefore, this research proposes a new simplified overall performance evaluation method for heat exchangers, which can be comprehensively and easily applied and takes into consideration the heat transfer performance and the pressure drop. The evaluation results on plate-type heat exchangers show that the overall performance in each heat exchanger are elucidated and are quantitatively compared.

Ocean thermal energy conversion (OTEC) is a heat engine application that utilizes the Rankine cycle to extract energy from the thermal gradient between surface seawater and deep seawater. Hybrid cycle OTEC (H-OTEC) is a combination of an open cycle desalination system and a closed-cycle power generation system that leverages the features of both cycles. Unlike other desalination technologies that require extensive energy to operate, H-OTEC relies entirely on renewable energy. In addition, a desalination plant can be coupled with the H-OTEC system (H-OTEC + D) to improve its performance. Conventionally, the total heat transfer area of heat exchangers per net power is used as an objective function to achieve optimal performance with the lowest capital expenditure cost. The proposed objective function, unlike the conventional one, considers both power and water. In this study, the optimization of H-OTEC + D and H-OTEC is carried out by minimizing the proposed objective function, considering several independent variables. The performance of both systems is evaluated in terms of the objective function, power consumption, seawater flow rates, and desalination ratio. The findings also indicate the effectiveness of the proposed objective function over the conventional one as an effective tool for maximizing power and desalinated water generation.

Incretin-based therapy consists of dipeptidyl peptidase-4 (DPP-4) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists. Whether switching from DPP-4 inhibitors to one of the GLP-1 receptor agonists, dulaglutide, has greater beneficial effects remains unknown. Therefore, this study aimed to investigate the effectiveness of switching from DPP-4 inhibitors to dulaglutide in four patients with type 2 diabetes. All four patients with hyperglycemia who switched from DPP-4 inhibitors to dulaglutide demonstrated noticeable decreased plasma glucose levels on the next day after switching. Two of the patients observed maintained a decreased plasma glucose level over 14 day after switching. Moreover, all patients demonstrated decreased glycosylated hemoglobin A1c levels during the observation period (1-6 months) after switching and lost weight from 6 to 27 day. Minor and manageable hypoglycemia, nausea, and diarrhea were observed as side effects in one case. The current findings suggest that dulaglutide is a suitable treatment alternative in patients with type 2 diabetes who are not currently achieving adequate glycemic control with DPP-4 inhibitors.