Land use and land cover changes (LULC) are one of the main factors in global environmental change, as well as one of the main causes of soil and biodiversity loss. The main objective of this research was to determine the dynamics of land use changes in the Bustillos basin located in the municipality of Cuauhtémoc, Chihuahua, Mexico. The research consisted of the processing and analysis of satellite images from Landsat Thematic Mapper (TM5) and Landsat Operational Land Imager (OLI8). From the classifications obtained through satellite images, six categories of land use were obtained and later were compared through the use of a cross-tabulation matrix. The results showed that the use of remote sensors applied to the evaluation of the dynamics of land use changes allowed for knowing the changes that occurred in a period of 43 years. To compare the land use of the years 1974 and 2016, maps were obtained with soil covers. This served as the basis for the analysis of the changes that occurred. In this way, it was possible to determine the growth of the urban area (7851.48 hectares) due to the development of economic activity and the increase in population. The category that had a more significant increase was the agricultural areas with a gain in surface of the sub-basin of 28,334.23 hectares. The grassland class lost 21,385.28 hectares; this area was associated with the class of agricultural areas and urban areas. The oak–pine forest had losses of 9150.03 hectares, as well as the pine forest (586.06 hectares). Finally, the class of water bodies lost 228.02 hectares. The results showed that the implementation of dynamic LULC using geographic information systems could be adopted as a planning tool to manage LULC in the Bustillos basin in the future.