Background/Objectives: We introduce a new surgical technique for inserting the eyePlate-300—a glaucoma drainage device (GDD). The flexibility of the eyePlate-300 allows for folding and insertion through a smaller conjunctival incision. The procedure is termed minimally invasive tube surgery (MITS). Methods: We performed a retrospective analysis of thirteen eyes to assess the efficacy of the MITS technique in a large London tertiary teaching eye hospital with 12 months follow-up. The primary outcome was complete success: defined as ‘IOP > 5 mmHg, <21 mmHg and off drops’. Secondary outcomes: best corrected visual acuity at 12 months, complications, a reduction in the number of drops and need for further pressure-lowering surgery. Results: Twelve eyes (92%) achieved a lower IOP. The mean pre-operative IOP was 35.69 mmHg (20–53 mmHg); post-operatively, it was reduced to 11.08 mmHg (5–20 mmHg) (p < 0.001). The mean pre-operative drops were 3.462 (3–4), reducing to 0.85 (0–3) at 12 months (p < 0.001). There was no change in the mean BCVA. No intraoperative complications were recorded, and no further IOP lowering surgeries were required. Conclusions: The MITS technique facilitates the implantation of a glaucoma drainage device through a smaller, less traumatic incision. Preliminary one-year data suggest that the procedure may be safe and effective.