This study investigates the alignment of research on small island developing states (SIDSs) with sustainable development goals (SDGs), identifying key focus areas, interdisciplinary connections, research gaps, thematic clusters, and insights from case studies. By employing a mixed methods research design that combines quantitative scientometric analysis with qualitative case studies, this unique study examines the nexus between SIDS research and its contribution to SDGs. The findings reveal that SDG 13 (climate action) and SDG 14 (life below water) dominate SIDS research, emphasizing the need to address climate challenges and marine biodiversity. Economic aspects are underscored by SDG 8 (decent work and economic growth) and SDG 12 (responsible consumption and production), while urban development and inequality are addressed through SDG 11 (sustainable cities and communities) and SDG 10 (reduced inequalities). Renewable energy and food security are focal points in SDG 7 (affordable and clean energy) and SDG 2 (zero hunger). Moderate research outputs in SDG 3 (good health and well-being) and SDG 15 (life on land) suggest a holistic approach, while lower activity in SDGs 16 (peace), 6 (clean water), 4 (education), and 5 (gender) presents opportunities for further exploration. SIDS research is highly interdisciplinary, as seen through three distinct SDG networks: foundational social goals, economic and environmental objectives, and environmental preservation. The thematic clusters in SIDS research include environmental challenges and adaptation, public health, and socioeconomic development, and energy policy and environmental economics. Case studies from various SIDSs illustrate the complex interplay between environmental sustainability, economic development, and social well-being, highlighting the importance of tailored approaches, international cooperation, and local community engagement. These findings underscore the need for integrated research strategies to address the complex challenges of SIDSs, emphasizing climate action, sustainable economic practices, and comprehensive development approaches to achieve the SDGs effectively.