Walter Leal Filho

Prof. Walter Leal Filho

Hamburg University of Applied Sciences
+1
orcid

Research Focus & Metrics

Academic Career Length

62Years (1965-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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7 January 2013 in Annual Review of Entomology
Verified
Journal Article
Closed access
Walter Leal FilhoWalter Leal Filho
Walter Leal Filho
Our knowledge of the molecular basis of odorant reception in insects has grown exponentially over the past decade. Odorant receptors (ORs) from moths, fruit flies, mosquitoes, and the honey bees have been deorphanized, odorant-degrading enzymes (ODEs) have been isolated, and the functions of odorant-binding proteins (OBPs) have been unveiled. OBPs contribute to the sensitivity of the olfactory system by transporting odorants through the sensillar lymph, but there are competing hypotheses on how they act at the end of the journey. A few ODEs that have been demonstrated to degrade odorants rapidly may act in signal inactivation alone or in combination with other molecular traps. Although ORs in Drosophila melanogaster respond to multiple odorants and seem to work in combinatorial code involving both periphery and antennal lobes, reception of sex pheromones by moth ORs suggests that their labeled lines rely heavily on selectivity at the periphery.

1 September 2019 in Journal of Cleaner Production
Verified
Journal Article
Closed access
Walter Leal FilhoWalter Leal Filho
Walter Leal Filho
CSChris Shiel
Chris Shiel
Arminda  PaçoArminda Paço
Arminda Paço
Mark MifsudMark Mifsud
Mark Mifsud
LÁLucas Veiga Ávila
Lucas Veiga Ávila
SCSandra Caeiro
Sandra Caeiro

1 October 2018 in Journal of Cleaner Production
Verified
Journal Article
Closed access
Rodrigo CaiadoRodrigo Caiado
Rodrigo Caiado
Walter Leal FilhoWalter Leal Filho
Walter Leal Filho
OQOsvaldo Luiz Gonçalves Quelhas
Osvaldo Luiz Gonçalves Quelhas
DNDaniel Nascimento
Daniel Nascimento
LÁLucas Veigas Ávila
Lucas Veigas Ávila

1 January 2019 in Journal of Cleaner Production
Verified
Journal Article
Closed access
Amanda Lange SalviaAmanda Lange Salvia
Amanda Lange Salvia
Walter Leal FilhoWalter Leal Filho
Walter Leal Filho
LBLuciana Londero Brandli
Luciana Londero Brandli
JGJuliane Sapper Griebeler
Juliane Sapper Griebeler

27 August 2018 in International Journal of Sustainable Development & World Ecology
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Journal Article
Closed access
Walter Leal FilhoWalter Leal Filho
Walter Leal Filho
STS. K. Tripathi
S. K. Tripathi
José Baltazar Salgueirinho Osório de Andrade GuerraJosé Baltazar Salgueirinho Osório de Andrade Guerra
José Baltazar Salgueirinho Osório de Andrade Guerra
Ricard Giné GarrigaRicard Giné Garriga
Ricard Giné Garriga
VLV. Orlovic Lovren
V. Orlovic Lovren
JWJ. Willats
J. Willats
The United Nations General Assembly agreed and approved in September 2015 the document ‘2030 Agenda for Sustainable Development’, which contains a set of measures aiming to balance economic progress and protection of the environment, whilst at the same time remain aware of the need to address the many disparities still seen between industrialised and developing countries. The Agenda document consists of 17 Sustainable Development Goals (SDGs), which among many other tasks, intend to eradicate poverty and create better health conditions in both developed and developing countries. But despite the need for and the relevance of the SDGs, it is unclear how they may help to address present and future sustainability challenges. Based on the need to shed some light on such a relationship, this paper describes each of the SDGs, and offers an analysis of the extent to which their implementation may offer support to ongoing attempts to handle some of the pressing problems seen in pursuing sustainable development. Three case studies are presented to show in practice how best the SDGs can be handled. The paper concludes that the process of implementing the SDGs offers unrivalled opportunities to advance equal opportunity and foster economic empowerment, helping countries to promote the cause of sustainable development in their territories, hence benefiting their populations.

1 February 2000 in Chemistry & Biology
Verified
Journal Article
Open access
BSBenjamin H Sandler
Benjamin H Sandler
LNLarisa Nikonova
Larisa Nikonova
Walter Leal FilhoWalter Leal Filho
Walter Leal Filho
JCJon Clardy
Jon Clardy
Insects use volatile organic molecules to communicate messages with remarkable sensitivity and specificity. In one of the most studied systems, female silkworm moths (Bombyx mori) attract male mates with the pheromone bombykol, a volatile 16-carbon alcohol. In the male moth's antennae, a pheromone-binding protein conveys bombykol to a membrane-bound receptor on a nerve cell. The structure of the pheromone-binding protein, its binding and recognition of bombykol, and its full role in signal transduction are not known. The three-dimensional structure of the B. mori pheromone-binding protein with bound bombykol has been determined by X-ray diffraction at 1.8 A resolution. The pheromone binding protein of B. mori has six helices, and bombykol binds in a completely enclosed hydrophobic cavity formed by four antiparallel helices. Bombykol is bound in this cavity through numerous hydrophobic interactions, and sequence alignments suggest critical residues for specific pheromone binding.