To investigate how bedding planes affect the energy evolution and failure characteristics of transversely isotropic rock, uniaxial compression tests were conducted on soft–hard interbedded rock-like specimens with varying bedding angles (α) using the RMT-150B rock mechanics loading system. The test results indicate that throughout the loading process, the energy evolution shows obvious stage characteristics, and the change of α mainly affects the accelerating energy dissipation stage and the full energy release stage. With the increase of α, the ability of rock to resist deformation under the action of energy shows the characteristics of “strong–weak–strong”. The energy dissipation process is accelerated by medium angle bedding planes (α = 45°~60°). The precursor points of the ratios of dissipation energy to total energy (R_DT) and elastic energy to dissipation energy (R_ED) can be used to effectively predict early failure. With the gradual increase of α, the difficulty of crack development is gradually reduced. The changes of energy storage limitation and release rate of releasable elastic energy are the immanent cause of different macroscopic failure modes of specimens with varying α.