Objectives: The aim of this study was to examine the impact of physical activity levels and body mass index (BMI) on the quality of life among university students. Methods: The sample consisted of 495 students (176 males and 319 females). Physical activity was assessed using the International Physical Activity Questionnaire—Short Form (IPAQ-SF), while quality of life was measured using the WHOQOL-BREF questionnaire. Pearson’s correlation coefficient and regression analysis were employed to determine relationships and predictive influence. Data were analyzed using SPSS version 20, with the level of significance set at p < 0.05. Results: The results indicated that male students reported significantly higher levels of moderate and vigorous intensity physical activity compared to female students (p = 0.015 and p = 0.001, respectively), as well as higher scores in the physical health and social relationships domains of quality of life (p = 0.002 and p = 0.001, respectively). Both physical activity and BMI had a statistically significant impact on the physical health (p = 0.040 for males; p = 0.024 for females) and psychological health (p = 0.047 for males; p = 0.000 for females) domains. Specifically, moderate-intensity PA positively influenced physical health (β = 0.21, p = 0.005), while BMI was a predictor of psychological health in males (β = 0.18, p = 0.016). Among females, BMI negatively influenced physical health (β = −0.18, p = 0.002), and both low-intensity PA (β = 0.17, p = 0.002) and BMI (β = −0.21, p = 0.000) significantly affected psychological health. Conclusions: These findings underscore the importance of promoting diverse forms of physical activity and maintaining a healthy BMI in student populations, with consideration for gender-specific approaches to maximize quality of life outcomes.

Body mass index (BMI) and body image (BI) are constructs worth examining in the context of physical activity (PA), and they are both related to quality of life (QoL). PA, BMI, and BI should all be considered as associated parameters, and their effect on QoL should be examined and understood. This study aimed to determine the moderating role of PA in the relationship of BMI and BI with QoL. The sample of examinees consisted of 500 respondents (307 women; aged 39 ± 6 years). A physical activity self-evaluation questionnaire (IPAQ-SF) was used to estimate PA; BI was evaluated by using the Body Image Dimensional Assessment (BIDA) questionnaire, while QoL was determined with the WHOQOL-BREF questionnaire. The results showed that vigorous PA moderates the relationship between BMI and social relationships in adults (Sig. = 0.000). Walking and vigorous PA affect the relationship between BMI and environmental health (Sig. = 0.017 and Sig. = 0.049, respectively). Both walking (Sig. = 0.035) and moderate PA (Sig. = 0.032) alternate the relationships between BI and social relationships. Walking (Sig. = 0.000) and vigorous PA (Sig. = 0.016) moderate the relationship between BI and environmental health. The influence of PA on the moderation of the relationship of BMI and BI with physical and psychological health in the working population was not statistically significant.