Bai-Shan Fang

Prof. Dr. Bai-Shan Fang


Research Focus & Metrics

Academic Career Length

16Years (2011-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 February 2019 in Journal of Functional Foods
Verified
Journal Article
Closed access
YFYOUSI FU
YOUSI FU
JZJunnan Zhang
Junnan Zhang
KCKainan Chen
Kainan Chen
CXChuanxing Xiao
Chuanxing Xiao
LFLina Fan
Lina Fan
BFBai-Shan Fang
Bai-Shan Fang

10 March 2016 in Biotechnology for Biofuels
Verified
Journal Article
Open access
PDF file
YZYa-Juan Zheng
Ya-Juan Zheng
BFBai-Shan Fang
Bai-Shan Fang
YWYuanpeng Wang
Yuanpeng Wang
BFBai-Shan Fang
Bai-Shan Fang
Biodiesel can replace petroleum diesel as it is produced from animal fats and vegetable oils, and it produces about 10 % (w/w) glycerol, which is a promising new industrial microbial carbon, as a major by-product. One of the most potential applications of glycerol is its biotransformation to high value chemicals such as 1,3-propanediol (1,3-PD), dihydroxyacetone (DHA), succinic acid, etc., through microbial fermentation. Glycerol dehydratase, 1,3-propanediol dehydrogenase (1,3-propanediol-oxydoreductase), and glycerol dehydrogenase, which were encoded, respectively, by dhaB, dhaT, and dhaD and with DHA kinase are encompassed by the dha regulon, are the three key enzymes in glycerol bioconversion into 1,3-PD and DHA, and these are discussed in this review article. The summary of the main research direction of these three key enzyme and methods of glycerol bioconversion into 1,3-PD and DHA indicates their potential application in future enzymatic research and industrial production, especially in biodiesel industry.

1 June 2023 in Synthetic and Systems Biotechnology
Verified
Journal Article
Open access
BRBi Ruomeng
Bi Ruomeng
OMOu Meihao
Ou Meihao
ZSZhou Siru
Zhou Siru
GSGeng Shichen
Geng Shichen
ZYZheng Yixian
Zheng Yixian
BFBai-Shan Fang
Bai-Shan Fang
The past 50 years have witnessed a massive expansion in the demand and application of pesticides. However, pesticides are difficult to be completely degraded without intervention hence the pesticide residue could pose a persistent threat to non-target organisms in many aspects. To aim at the problem of the abuse of pesticide products and excessive pesticide residues in the environment, chemical and biological degradation methods are widely developed but are scaled and insufficient to solve such a pollution. In recent years, bio-degradative tools instructed by synthetic biological principles have been further studied and have paved a way for pesticide degradation. Combining the customized design strategy and standardized assembly mode, the engineering bacteria for multi-dimensional degradation has become an effective tool for pesticide residue degradation. This review introduces the mechanisms and hazards of different pesticides, summarizes the methods applied in the degradation of pesticide residues, and discusses the advantages, applications, and prospects of synthetic biology in degrading pesticide residues.

6 March 2023 in Nature Catalysis
Verified
Journal Article
Closed access
PDF file
AZAihui Zhang
Aihui Zhang
XZXiaoyan Zhuang
Xiaoyan Zhuang
JLJia Liu
Jia Liu
JHJiacheng Huang
Jiacheng Huang
LLLuchun Lin
Luchun Lin
WHWenjing Hong
Wenjing Hong

20 April 2017 in Critical Reviews in Biotechnology
Verified
Journal Article
Closed access
SWShi-Zhen Wang
Shi-Zhen Wang
YZYong-Hui Zhang
Yong-Hui Zhang
HRHong Ren
Hong Ren
YWYa-Li Wang
Ya-Li Wang
WJWei Jiang
Wei Jiang
BFBai-Shan Fang
Bai-Shan Fang
Multi-enzyme complexes have the potential to achieve high catalytic efficiency for sequence reactions due to their advantages in eliminating product inhibition, facilitating intermediate transfer and in situ regenerating cofactors. Constructing functional multi-enzyme systems to mimic natural multi-enzyme complexes is of great interest for multi-enzymatic biosynthesis and cell-free synthetic biotransformation, but with many challenges. Currently, various assembly strategies have been developed based on the interaction of biomacromolecules such as DNA, peptide and scaffolding protein. On the other hand, chemical-induced assembly is based on the affinity of enzymes with small molecules including inhibitors, cofactors and metal ions has the advantage of simplicity, site-to-site oriented structure control and economy. This review summarizes advances and progresses employing these strategies. Furthermore, challenges and perspectives in designing multi-enzyme systems are highlighted.

22 April 2020 in Applied Biochemistry and Biotechnology
Verified
Journal Article
Closed access
PDF file
WJWei Jiang
Wei Jiang
BFBai-Shan Fang
Bai-Shan Fang