The widespread use of MLT may pose numerous hazards to animal breeding, health, and resilience due to the presence of MLT residues in animal feedstuffs, pastures, hay, and cereals. Many medicinal plants provide what is called a generalized anti-toxic remedy. The current study examined hazardous biochemical and histological reactions to MLT and the efficiency of ThEO and OEO essential oils as anti-toxic therapies to return to a natural state after MLT exposure. A total of 75 male albino rats were randomly assigned to two groups: (i) C − MLT, comprising 25 rats, served as the control group; and (ii) C + MLT, with 50 rats that were exposed to 5 mg/kg/BW. After exposure to MLT for 21 days, a return to normal status was determined by subdividing the C + MLT group into two equal groups: ThEO and OEO were used as treatments, with 100 mg/kg body weight of thyme and oregano essential oils, respectively, being administered for 21 days. The results showed a significant decrease in body weight gain (BWG) and final weight (FW) compared to C − MLT, while the therapeutic effects of ThEO and OEO enhanced FW and BWG. Our results indicated that MLT exposure resulted in deficient serum liver function, but that OEO and ThEO therapy brought about a significant improvement in liver enzyme function. Although there was no significant difference in serum aspartate transaminase (AST) or alkaline phosphatase (ALK-Ph) and a significant drop in alanine transaminase (ALT) and acetyl choline-esterase (AChE) levels, the C + MLT group showed hepatic fibrosis in the third stage. Furthermore, histological sections of the OEO and ThEO groups showed reduced hepatocellular damage, inflammation, and hepatic fibrosis. However, there was a significant increase in serum creatinine between the C + MLT and C − MLT groups following exposure to MLT. Histological sections of renal tissue from rats treated with OEO and ThEO showed reduced tubular damage, reduced interstitial inflammation, and preserved renal tissue architecture. In conclusion, OEO and ThEO are potential compounds for use as anti-toxic therapies to return to a natural state after MLT exposure. These compounds could serve as an experimental therapeutic approach against natural toxins, providing a solution to the problems of raising livestock that are exposed to nutritional toxicity.

This experiment was conducted to study the effects of some medicinal plants on bone formation and bone resorption in normal and diabetic rats. The studies included two experiments; the first was in summer while the second was in winter season. Each experiment included 120 adult male albino rats averaged 100±10 gm live body weight. Normal rats were distributed into 4 groups (15 rats each). Group1 fed control diet, Group2 fed garlic 5%, Group3 fed Nigella sativa 5%, Group4 fed garlic 2.5% + Nigella sativa 2.5 %, while four groups included diabetic rats, Group5 (Control), Group6 fed garlic 5 %, Group7 fed Nigella sativa 5% and Group8 fed garlic 2.5% + Nigella sativa 2.5%. Blood samples were collected after 4 and 8 weeks from the start of the experiment and centrifuged at 3000 rpm for 15 minutes to obtain serum. Results show that serum lactic dehydrogenase, alkaline phosphatases, glucose and parathyroid hormone were significantly increased in diabetic rats than normal rats while treatment of diabetic rats with medicinal plants efficiently modify this effect. Serum osteocalcin was significantly decreased in diabetic rats than normal rats. Conclusion, treatment with medicinal plant has a beneficial effect on regulating bone formation and resorption either in normal or diabetic rats.

A total number of 35 Male albino rats were obtained from El Osman Farm, Cairo, Egypt. Animals were housed in stainless steel cages and provided with food and water ad libitum. All animals were healthy and clinically free of diseases. Rats were randomly divided into 5 equal groups, each group contained 7 rats and fed on one of the following diets: Group 1: Control diet, Group 2: Control diet + 1000ppm Aluminum, Group 3: Control diet+ 1000ppm+Garlic 5%, Group 4: Control diet+ 1000ppm + Nigella sativa 5%, Group 5: Control diet+ 1000ppm + Garlic 2.5 %+ Nigella sativa 2.5%. Blood samples were collected of each group after 30 and 60days from the beginning of the experiment. Blood samples were centrifuged at 3000 rpm for 15 min. and serum was separated and kept in frozen until subsequent analyses. And at the end of the experiment blood samples were collected too in EDTA tubes for Determination the hematological parameters. Finally, at the end of the experiment, rats were sacrificed to obtain the livers, and kidneys for examination it. The results indicated that Aluminum has adverse effects on animal and human health. The present study demonstrated that medicinal plants (garlic and nigella) in combination with aluminum minimized its hazards. Consequently, the exposure to aluminum should be reduced and attention paid to sources of aluminum in foods, water and personal care products. Furthermore, using diets rich in medicinal plants (garlic and nigella) could be beneficial in alleviating aluminum toxicity.

Twenty dry, nonpregnant ossimi ewes were used to examine how several physiological parameters were affected by a oneday exposure to heat stress. Animals were split equally into two groups, with each group consisting of two experimental ewes, each of which was aged 3–4 years and weighed 35–40 kg (NRC 1988). The trial began on July 15, 2019, and ended on December 1. On the first day of the experiment, the first group was subjected to heat stress for a whole day. The control group was kept in the shadow until the experiment's conclusion. The levels of creatinine, haemoglobin (HB), glutathione peroxidase, total antioxidant capacity, glutathiones transferase, (ALT & AST), and body temperature were measured. The findings demonstrated that although the control group underwent no changes, those exposed to just one day of summertime direct heat experienced an increase in oxidative stress enzymes. That also happened when people were exposed to direct cold for one day during the winter, which increased their levels of oxidative enzymes in comparison to the control group. This is referring to exposure to direct heat or direct cold that affects an animal's immunity and causes an increase in enzymes as a defence mechanism the animal uses to withstand pressure.

The goal of the current investigation was to determine whether LUPINES (termis) have an antihyperglycemic effect on diabetic rats produced by alloxan. El Osman Farm in Cairo, Egypt provided a total of 40 male albino rats. Animals were kept in stainless steel cages with unlimited access to food and water. Each animal was sound and clinically disease-free. Four equal groups of 10 rats each were formed by randomly dividing the rats into groups, and each group received one of the following diets: Group 1: Normal Control feed normal diet; Group 2: Normal rat feed normal diet plus 5% Lupines; Group 3: Diabetic rat feed normal diet; Group 4: Diabetic rat feed normal diet plus 5% Lupines. Each group had blood samples taken after 30 and 60 days since the experiment's start. Blood samples were centrifuged at 3000 rpm for 15 minutes to separate the serum, which was then stored in the freezer for later analysis. Also, blood samples were collected at the conclusion of the experiment to be used in the determination of the hematological parameters. The current study showed that LUPINES (termis) medicinal herbs reduced the risks associated with diabetes. Therefore, it is important to pay attention to the sources of LUPINES (termis) in foods. Moreover, eating diets high in LUPINES (termis) medicinal herbs may help reduce the risks associated with diabetes.Keywords: alloxan, hypoglycemic, Lupines