The capability of prompt response in the case of critical circumstances occurring within a maritime scenario depends on the awareness level of the competent authorities. From this perspective, a quick and integrated surveillance service represents a tool of utmost importance. This is even more true when the main purpose is to tackle illegal activities such as smuggling, waste flooding, or malicious vessel trafficking. This work presents an improved version of the OSIRIS system, a previously developed Information and Communication Technology framework devoted to understanding the maritime vessel traffic through the exploitation of optical and radar data captured by satellite imaging sensors. A number of dedicated processing units are cascaded with the objective of (i) detecting the presence of vessel targets in the input imagery, (ii) estimating the vessel types on the basis of their geometric and scatterometric features, (iii) estimating the vessel kinematics, (iv) classifying the navigation behavior of the vessel and predicting its route, and, eventually, (v) integrating the several outcomes within a webGIS interface to easily assess the traffic status inside the considered area. The entire processing pipeline has been tested on satellite imagery captured within the Mediterranean Sea or extracted from public annotated datasets.

3-Iodothyronamine (T₁AM) is an endogenous biogenic amine, structurally related to thyroid hormone, which is regarded as a novel chemical messenger. The molecular mechanisms underlying T₁AM effects are not known, but it is possible to envisage changes in gene expression, since delayed and long-lasting phenotypic effects have been reported, particularly with regard to the modulation of lipid metabolism and body weight. To test this hypothesis we analysed gene expression profiles in adipose tissue and liver of eight rats chronically treated with T₁AM (10 mg/Kg twice a day for five days) as compared with eight untreated rats. In vivo T₁AM administration produced significant transcriptional effects, since 378 genes were differentially expressed in adipose tissue, and 114 in liver. The reported changes in gene expression are expected to stimulate lipolysis and beta-oxidation, while inhibiting adipogenesis. T₁AM also influenced the expression of several genes linked to lipoprotein metabolism suggesting that it may play an important role in the regulation of cholesterol homeostasis. No effect on the expression of genes linked to toxicity was observed. The assay of tissue T₁AM showed that in treated animals its endogenous concentration increased by about one order of magnitude, without significant changes in tissue thyroid hormone concentration. Therefore, the effects that we observed might have physiological or pathophysiological importance. Our results provide the basis for the reported effectiveness of T₁AM as a lipolytic agent and gain importance in view of a possible clinical use of T₁AM in obesity and/or dyslipidaemia.

Alzheimer’s disease (AD) is a complex neurodegenerative condition characterized by a multifaceted interplay of genetic, environmental, and pathological factors. Traditional diagnostic and research methods, including neuropsychological assessments, imaging, and cerebrospinal fluid (CSF) biomarkers, have advanced our understanding but remain limited by late-stage detection and challenges in modeling disease progression. The emergence of three-dimensional (3D) brain organoids (BOs) offers a transformative platform for bridging these gaps. BOs derived from patient-specific induced pluripotent stem cells (iPSCs) mimic the structural and functional complexities of the human brain. This advancement offers an alternative or complementary approach for studying AD pathology, including β-amyloid and tau protein aggregation, neuroinflammation, and aging processes. By integrating biological complexity with cutting-edge technological tools such as organ-on-a-chip systems, microelectrode arrays, and artificial intelligence-driven digital twins (DTs), it is hoped that BOs will facilitate real-time modeling of AD progression and response to interventions. These models capture central nervous system biomarkers and establish correlations with peripheral markers, fostering a holistic understanding of disease mechanisms. Furthermore, BOs provide a scalable and ethically sound alternative to animal models, advancing drug discovery and personalized therapeutic strategies. The convergence of BOs and DTs potentially represents a significant shift in AD research, enhancing predictive and preventive capacities through precise in vitro simulations of individual disease trajectories. This approach underscores the potential for personalized medicine, reducing the reliance on invasive diagnostics while promoting early intervention. As research progresses, integrating sporadic and familial AD models within this framework promises to refine our understanding of disease heterogeneity and drive innovations in treatment and care.

The main purpose of this paper is to describe a software platform dedicated to sea surveillance, capable of detecting and identifying illegal maritime traffic. This platform results from the cascade pipeline of several image processing algorithms that input Radar or Optical imagery captured by satellite-borne sensors and try to identify vessel targets in the scene and provide quantitative descriptors about their shape and motion. This platform is innovative since it integrates in its architecture heterogeneous data and data processing solutions with the goal of identifying navigating vessels in a unique and completely automatic processing streamline. More in detail, the processing chain consists of: (i) the detection of target vessels in an input map; (ii) the estimation of each vessel’s most descriptive geometrical and scatterometric (for radar images) features; (iii) the estimation of the kinematics of each vessel; (iv) the prediction of each vessel’s forthcoming route; and (v) the visualization of the results in a dedicated webGIS interface. The resulting platform represents a novel tool to counteract unauthorized fishing and tackle irregular migration and the related smuggling activities.

We present a strategy to estimate the heading, the length overall and the beam overall of targets already detected as ships in a wide-swath SAR image acquired by a satellite platform. Such images are often affected by distortions due to marine clutter, spectral leakage, or antenna sidelobes. These can mask the target image, thus hampering the possibility of evaluating the size and the behaviour of the ship. Even in the presence of strong artefacts, we found that the principal inertia axes can help the estimation of the target heading and be included in an iterative procedure to erode the false target features, so to enable a more accurate evaluation of the overall measurements of the ship. Here we introduce our idea and present some results obtained from real SAR images.