The current study aimed to compare the mechanical properties of CAD/CAM fabricated hybrid ceramic restorative materials. The current study assessed the mechanical properties of additively and subtractively manufactured CAD/CAM fabricated hybrid ceramic by conducting flexure strength test, compressive strength test, and Vickers hardness test. Flexural samples were subjected to a three-point bending test using a universal testing machine until the samples showed fracture. Moreover, samples for the compressive strength test were subjected to compression tests using a universal testing machine until samples were fractured. Samples for the Vickers hardness was tested using the Vickers hardness testing machine to determine the sample’s hardness values. There were significant differences (p = 0.0001) were observed among the additive and subtractive groups in terms of flexure strength and compressive strength test. Regarding the Vickers hardness test, significant differences (p = 0.0001) were observed between the polished and unpolished groups in additive manufacturing. However, no significant (p = 0.681) differences were observed in the subtractive manufacturing technique. The subtractive group achieved ISO specifications in terms of flexural strength and was superior to additive groups in hardness while exhibiting lower performance in compressive strength. Moreover, printing orientation had a significant influence on the performance of additive groups. Flexural strength and hardness were improved when the printing orientation was in alignment with the direction of load (90°) while compressive strength was improved when the printing orientation was perpendicular to the direction of load (0°).