The energy industry is experiencing a major change due to fast progress in artificial intelligence (AI). Startup companies in this revolution use AI technologies like Machine Learning (ML), predictive analytics, and optimization algorithms to improve energy efficiency, optimize grid management, and incorporate renewable energy sources. AI-powered solutions allow for a more accurate prediction of demand, immediate monitoring, and automated decision-making processes, significantly enhancing operational efficiency and sustainability. Through promoting a more effective energy system, these advancements play a vital role in the worldwide battle against climate change and carbon dioxide emissions. Adding to the progress of AI, quantum computing (QC) shows great potential despite being a nascent area. The collaboration of AI and QC is poised to transform the energy industry by offering unmatched computational capabilities. This blend of technologies can tackle intricate energy obstacles like enhancing power grids and enhancing battery storage, which traditional computers cannot currently handle. Combining QC with AI speeds up innovation, providing advanced solutions that improve the resilience and efficiency of energy networks. This paper discusses the latest advancements, possible effects, and upcoming paths of new companies leading in AI and QC innovations within the energy industry. Their joint responsibility is highlighted in advancing a sustainable and intelligent energy future, as well as tackling crucial environmental issues and lessening the impact of climate change.

Background: Timely recognition of cancer progression and treatment complications is important for treatment guidance. Digital phenotyping is a promising method for precise and remote monitoring of patients in their natural environments by using passively generated data from sensors of personal wearable devices. Further studies are needed to better understand the potential clinical benefits of digital phenotyping approaches to optimize care of patients with cancer. Objective: We aim to evaluate whether passively generated data from smartphone sensors are feasible for remote monitoring of patients with cancer to predict their disease trajectories and patient-centered health outcomes. Methods: We will recruit 200 patients undergoing treatment for cancer. Patients will be followed up for 6 months. Passively generated data by sensors of personal smartphone devices (eg, accelerometer, gyroscope, GPS) will be continuously collected using the developed LAIMA smartphone app during follow-up. We will evaluate (1) mobility data by using an accelerometer (mean time of active period, mean time of exertional physical activity, distance covered per day, duration of inactive period), GPS (places of interest visited daily, hospital visits), and gyroscope sensors and (2) sociability indices (frequency of duration of phone calls, frequency and length of text messages, and internet browsing time). Every 2 weeks, patients will be asked to complete questionnaires pertaining to quality of life (European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire [EORTC QLQ-C30]), depression symptoms (Patient Health Questionnaire-9 [PHQ-9]), and anxiety symptoms (General Anxiety Disorder-7 [GAD-7]) that will be deployed via the LAIMA app. Clinic visits will take place at 1-3 months and 3-6 months of the study. Patients will be evaluated for disease progression, cancer and treatment complications, and functional status (Eastern Cooperative Oncology Group) by the study oncologist and will complete the questionnaire for evaluating quality of life (EORTC QLQ-C30), depression symptoms (PHQ-9), and anxiety symptoms (GAD-7). We will examine the associations among digital, clinical, and patient-reported health outcomes to develop prediction models with clinically meaningful outcomes. Results: As of July 2023, we have reached the planned recruitment target, and patients are undergoing follow-up. Data collection is expected to be completed by September 2023. The final results should be available within 6 months after study completion. Conclusions: This study will provide in-depth insight into temporally and spatially precise trajectories of patients with cancer that will provide a novel digital health approach and will inform the design of future interventional clinical trials in oncology. Our findings will allow a better understanding of the potential clinical value of passively generated smartphone sensor data (digital phenotyping) for continuous and real-time monitoring of patients with cancer for treatment side effects, cancer complications, functional status, and patient-reported outcomes as well as prediction of disease progression or trajectories. International Registered Report Identifier (IRRID): PRR1-10.2196/49096

BACKGROUND Timely recognition of cancer progression and treatment complications is important for treatment guidance. Digital phenotyping is a promising method for precise and remote monitoring of patients in their natural environments by using passively generated data from sensors of personal wearable devices. Further studies are needed to better understand the potential clinical benefits of digital phenotyping approaches to optimize care of patients with cancer. OBJECTIVE We aim to evaluate whether passively generated data from smartphone sensors are feasible for remote monitoring of patients with cancer to predict their disease trajectories and patient-centered health outcomes. METHODS We will recruit 200 patients undergoing treatment for cancer. Patients will be followed up for 6 months. Passively generated data by sensors of personal smartphone devices (eg, accelerometer, gyroscope, GPS) will be continuously collected using the developed LAIMA smartphone app during follow-up. We will evaluate (1) mobility data by using an accelerometer (mean time of active period, mean time of exertional physical activity, distance covered per day, duration of inactive period), GPS (places of interest visited daily, hospital visits), and gyroscope sensors and (2) sociability indices (frequency of duration of phone calls, frequency and length of text messages, and internet browsing time). Every 2 weeks, patients will be asked to complete questionnaires pertaining to quality of life (European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire [EORTC QLQ-C30]), depression symptoms (Patient Health Questionnaire-9 [PHQ-9]), and anxiety symptoms (General Anxiety Disorder-7 [GAD-7]) that will be deployed via the LAIMA app. Clinic visits will take place at 1-3 months and 3-6 months of the study. Patients will be evaluated for disease progression, cancer and treatment complications, and functional status (Eastern Cooperative Oncology Group) by the study oncologist and will complete the questionnaire for evaluating quality of life (EORTC QLQ-C30), depression symptoms (PHQ-9), and anxiety symptoms (GAD-7). We will examine the associations among digital, clinical, and patient-reported health outcomes to develop prediction models with clinically meaningful outcomes. RESULTS As of July 2023, we have reached the planned recruitment target, and patients are undergoing follow-up. Data collection is expected to be completed by September 2023. The final results should be available within 6 months after study completion. CONCLUSIONS This study will provide in-depth insight into temporally and spatially precise trajectories of patients with cancer that will provide a novel digital health approach and will inform the design of future interventional clinical trials in oncology. Our findings will allow a better understanding of the potential clinical value of passively generated smartphone sensor data (digital phenotyping) for continuous and real-time monitoring of patients with cancer for treatment side effects, cancer complications, functional status, and patient-reported outcomes as well as prediction of disease progression or trajectories. INTERNATIONAL REGISTERED REPORT PRR1-10.2196/49096

The extreme volatility of European energy markets in 2022 has exposed the limitations of conventional forecasting models, necessitating more robust architectures capable of handling non-linear price shocks. This study proposes a novel multi-parallel hybrid forecasting framework that integrates seven heterogeneous neural networks to predict day-ahead electricity prices. The architecture employs a hierarchical approach where six parallel base models (NN1–NN6) feed into a meta-network (NN7) to generate baseline forecasts. To further enhance predictive fidelity, these results undergo a calibration stage using probabilistic error distribution analysis to produce final probability-adjusted forecasts. The model was validated using the Lithuanian electricity market during the highly volatile period of 2020–2022. Empirical results demonstrate a clear “stacking effect,” where the incremental integration of base networks consistently reduces forecasting residuals. The final probability-adjusted configuration achieved a notable nMAE of 1.57% and a sMAPE of 34.25%, significantly outperforming baseline ensemble outputs and state-of-the-art benchmarks reported in recent literature. Specifically, the probability-based refinement proved highly effective in mitigating systematic biases during nighttime and early morning hours, confirming the model’s capacity to maintain accuracy under extreme market stress.