Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that impairs cognitive and psychological performance and adversely impacts daily routines and activities. We hypothesized that Binaural beat stimulation (BBS) enhances psychological performance by increasing connectivity in the θ- and α- bands over the fronto-parietal region. Twenty-five AD patients received either Binaural beat (BBS) or Standard Auditory beat stimulation (SAS) for 12 consecutive days. Psychometric assessments (Blessed Dementia Scale, Depression Anxiety Stress Scale, and Mini-Mental State Examination) and a 38-channel EEG were conducted on Day 1 and Day 14. Independent t-tests (p< 0.05) compared the pre- and post-states of both groups. The neurological analysis was conducted using brain functional connectivity, including imaginary coherence and graph-theory parameters. Two-way ANOVA examined the effects of group and intervention on behavioral and connectivity outcomes, while Pearson’s correlation assessed the relationship between behavioral improvements and graph-theoretical metrics. The findings reveal significant changes in the network dynamics of the BBS group, including increased long-range θ-band connectivity and enhanced local α-band processing. These neural changes corresponded with improved cognitive and daily functioning, reflected by decreased BDS and DASS-21 scores and increased MMSE scores. This highlights the positive impact of BBS on AD patients’ neurological, psychological, and behavioral responses, suggesting a promising intervention for cognitive and psychological advancement in AD.

Background: The global prevalence of Alzheimer’s disease (AD) has reached 55.2 million. AD is characterized by progressive deterioration in cognition and working memory (WM), which are essential for attention, reasoning, and learning. These impairments are associated with pathological changes in cortical and subcortical regions. Binaural beats (BBs), a non-invasive auditory neuromodulation technique, have demonstrated cognitive enhancement effects in healthy individuals; however, their impact on WM in patients with AD remains largely unexplored. Methods: This study investigated the effects of BB stimulation on WM and cognitive function in the temporal lobe of patients with AD using standardized Low-Resolution Electromagnetic Tomography (sLORETA). Twenty-five patients with AD were randomly assigned to either an experimental group (n = 15) that received BB stimulation or a control group (n = 10) that received standard auditory stimulation. EEG recordings were obtained before and after the intervention. Results: Paired t-tests conducted on timeframe and frequency-wise sLORETA images revealed significant increases (p < 0.05) in theta, alpha1, and alpha2 frequency bands in the experimental group. Activated regions included the inferior, middle, superior, and transverse temporal gyri; Brodmann areas (BA) 20, 21, 22, 40, and 42; as well as networks associated with working memory and cognition. Conclusions: These findings suggest that BB stimulation induces temporal lobe activation, thereby enhancing working memory and cognitive function in patients with AD.