Obesity epidemic and prevailing standards of desired body shape encourage society to use weight loss aids. Thermogenics, which are dietary supplements aimed at increasing energy expenditure, are particularly gaining popularity. These preparations can be easily purchased without prescription and have a complex composition, which means they can interact with numerous substances. The article describes the case of a 31-year-old female patient who, in a suicide attempt, ingested significant amounts of the dietary supplements ‘Blue Magic’ and ‘Purim’. Both supplements contain, among other ingredients: caffeine, yohimbine, reserpine, and synephrine. The patient developed multiple organ failure, which led to her death on the second day of hospitalization. Poisoning by dietary supplements, due to their diverse composition and the lack of correlation between the content and the composition declared by the manufacturer, can pose a significant threat to the health and life of consumers.

Background: The text discusses the case of a patient who experienced pneumopericardium because of a traumatic incident. It discusses pneumopericardium’s causes, symptoms, and complications, including tamponade symptoms and imaging modalities, to confirm the diagnosis and assess complications. Present various treatment options emphasize the importance of ongoing monitoring and damage control principles. Methods: Retrieved pneumopericardium cases with complete clinical databases (Pubmed, Medline) and summarised the clinical symptoms and prognosis of different treatment schemes. Results: A 33-year-old male patient, after a suicide attempt, fell from a height estimated at 15 m. The patient was intubated at the scene and mechanically ventilated. Initial assessment revealed signs of tension pneumothorax, which was decompressed and stabilized. Subsequent deterioration led to the discovery of pneumopericardium through diagnostic imaging. Conclusions: The case highlights the need for a comprehensive and multidisciplinary approach to address the complex nature of injuries associated with pneumopericardium. It examines the principles of damage control, which focus primarily on the patient’s general condition, leaving some injuries for later treatment.

Insulin, produced by pancreatic β-cells, is a critical anabolic hormone that plays a pivotal role in the regulation of carbohydrate metabolism. Dysregulation of insulin secretion can pose significant threats to health and life, underscoring the importance of its discovery. The introduction of insulin as a therapeutic agent revolutionized diabetes management. Currently, human insulin and its analogs, manufactured through advanced genetic engineering techniques, are widely used. Despite more than a century of clinical use, efforts to improve insulin formulations continue, aiming to enhance patient comfort and reduce the frequency of injections. Insulin is also employed in the management of acute conditions, such as diabetic ketoacidosis and hyperglycemic hyperosmolar state, where intravenous administration is used to lower blood glucose levels effectively. Additionally, insulin is effective in the treatment of hyperkalemia and in cases of poisoning with calcium channel blockers and β-receptor antagonists. In these scenarios, insulin has the highest therapeutic recommendation class. High-dose insulin euglycemic therapy (HIET) is implemented using doses of approximately 1 IU/kg body weight, regardless of patient age, with careful maintenance of euglycemia. HIET is also considered in cases of poisoning with metal phosphides and refractory shock. Positive outcomes have been reported in the literature for patients treated with high-dose insulin for caffeine poisoning and venlafaxine toxicity. These isolated reports highlight the need for further research and development of insulin therapy in acute medical conditions, potentially expanding its applications beyond traditional indications.

Introduction and objective: Cannabis is one of the most widely used illegal stimulants in the world. With a worldwide usage rate of about 4% of the population, it definitely leaves other drugs behind. Currently, the trend of cannabis use is upward which is most visible in the adolescent and...