Allergic diseases are among the most common health issues children and adolescents face. Allergic reactions occur when the immune system becomes allergically sensitised and are detected by measuring levels of specific immunoglobulin E antibodies (IgE antibodies) in the blood. This article discusses the prevalences of bronchial asthma, hay fever, atopic dermatitis and allergic contact dermatitis for 0- to 17-year-olds, as well as the prevalence of allergic sensitisation to a mix of frequent inhalant allergens (SX1) among 3- to 17-year-olds based on data from the second wave of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS Wave 2, 2014-2017). 12-month prevalence trends between KiGGS Wave 2 and the KiGGS baseline study (2003-2006) are shown according to gender and age group. There were no significant changes in the 12-month prevalence of hay fever (8.8%) atopic dermatitis (7.0%) and bronchial asthma (3.5%) compared to the KiGGS baseline study, which indicates a stabilisation at a high level. More than one in six children (16.1%) currently suffer from at least one of these three diseases. 37.1% of 3- to 17-year-olds are sensitised to the multiple allergen mix SX1. Similar to the development of disease prevalence, SX1 sensitisation too has remained stable at a high level over the course of the past ten years.

Primary congenital hypothyroidism is easily diagnosed on the basis of elevated plasma levels of thyroid-stimulating hormone (TSH). In contrast, in the rare disorders of thyroid hormone resistance, TSH and, in mild cases, also thyroid hormone levels are within the normal range. Thyroid hormone resistance is caused by defects in hormone metabolism, transport, or receptor activation and can have the same serious consequences for child development as congenital hypothyroidism. A total of n = 23,522 data points from a large cohort of children and young adults were used to generate normal values and sex-specific percentiles for the ratio of free triiodothyronine (T3) to free thyroxine (T4), the fT3/fT4 ratio. The aim was to determine whether individuals with developmental delay and genetically confirmed thyroid hormone resistance, carrying defects in Monocarboxylate Transporter 8 (MCT8), Thyroid Hormone Receptor alpha (THRα), and Selenocysteine Insertion Sequence-Binding Protein 2 (SECISBP2), had abnormal fT3/fT4 ratios. Indeed, we were able to demonstrate a clear separation of patient values for the fT3/fT4 ratio from normal and pathological controls (e.g., children with severe cerebral palsy). We therefore recommend using the fT3/fT4 ratio as a readily available screening parameter in children with developmental delay for the identification of thyroid hormone resistance syndromes. The fT3/fT4 ratio can be easily plotted on centile charts using our free online tool, which accepts various SI and non-SI units for fT3, fT4, and TSH.

Gamma-glutamyl transferase (GGT) is a marker for cardiovascular risk and an independent predictor of long-term outcome in adults. Epidemiological data from pediatric cohorts are rare. We studied the association of GGT to body mass index as a standard deviation score, sex, and age in 68,415 children (age 11.7 ± 4.4 years; 48% boys; body mass index 27.2 ± 7.4 kg/m2; GGT measured in n = 23,955). GGT >50 U/L is strongly associated with extreme obesity (odds ratio 27.13, 95% confidence interval 15.07–48.85) and male sex (odds ratio 2.60, 95% confidence interval 2.03–3.31). GGT seems to be of clinical relevance and may be marketable as a surrogate in risk profiling for children with obesity.

Zusammenfassung Hintergrund SARS-CoV-2-Antikörperstudien ergänzen und erweitern die Erkenntnisse aus der Meldestatistik laborbestätigter COVID-19-Fälle um Informationen zu unentdeckten Fällen. Ziel der Arbeit Der vorliegende Beitrag fasst bisherige Ergebnisse zur SARS-CoV-2-Prävalenz aus seroepidemiologischen Studien in Deutschland zusammen, die sich auf Kinder und Jugendliche konzentrieren, und ergänzt die bereits vorliegende Übersicht zur Seroprävalenz bei Erwachsenen und speziell bei Blutspendenden in Deutschland. Material und Methoden Die Ergebnisse der Übersichtsarbeit beruhen auf einer fortlaufenden systematischen Recherche in Studienregistern, Literaturdatenbanken, von Preprint-Veröffentlichungen und Medienberichten seroepidemiologischer Studien in Deutschland sowie deren Ergebnissen. Ergebnisse Mit Stand 17.09.2021 sind uns 16 deutsche seroepidemiologische Studien, die sich auf Kinder und Jugendliche konzentrieren, bekannt geworden. Für 9 dieser Studien liegen Ergebnisse vor. Für fast alle untersuchten Settings lag die SARS-CoV-2-Seroprävalenz für Kinder im Kita- und Grundschulalter in der ersten COVID-19-Welle deutlich unter 1 % und für Jugendliche unter 2 %. Im Verlauf der Pandemie wurden höhere Seroprävalenzen von bis zu 8 % für Kinder im Grundschulalter ermittelt. Diskussion Ergebnisse von SARS-CoV-2-Antikörperstudien bei Kindern und Jugendlichen in Deutschland liegen bislang erst in geringem Umfang und basierend auf lokal-regionalen, nichtrepräsentativen Stichproben vor. In künftigen Studien gilt es, einerseits abzuschätzen, welcher Anteil der Kinder und Jugendlichen bereits eine Infektion hatte oder geimpft ist. Zum anderen gilt es, die Verbreitung körperlicher und psychischer Beeinträchtigungen im Nachgang einer Infektion zu untersuchen.

Knowledge of the risk of cardiovascular disease (CVD) is important for its prevention. Data from a non-clinical test for the absolute risk of having a heart attack or stroke for the first time in the next ten years is available from 3,271 35- to 69-year-old participants in the GEDA 2022 study without a diagnosis of heart attack or stroke. This risk was categorised as low (< 5 %), still low (≥ 5 % – < 7.5 %), increased (≥ 7.5 % – < 10 %) and high (≥ 10 %). In addition, the self-perceived CVD risk was asked as almost no, low, moderate and high risk. According to the CVD test, 73.5 % of adults were at low risk, 7.8 % were still at low risk, 6.0 % were at increased risk and 12.8 % were at high risk. In contrast, 28.7 % perceived themselves to be at almost no risk, 45.3 % at low risk, 20.4 % at moderate risk and 5.6 % at high risk of CVD. The higher the test-based risk, the lower the proportion of those who perceived themselves as having almost no or only a low risk. Nevertheless, half of the people with an increased to high risk according to the test result perceived themselves to be at almost no or only a low risk. The underestimation of risk was associated with lower education, better mental health and physical activity in both sexes. People who underestimate their risk of CVD despite an unfavourable risk factor profile are a key target group for cardiovascular prevention.