Rural revitalization, as a crucial strategic goal for rural development in contemporary China, encompasses multidimensional connotations and requirements. Following the establishment of the ‘three rights separation’ system in 2014, land transfer has increasingly assumed a vital role, demonstrating a close and complex intrinsic logical relationship with rural revitalization. To comprehensively analyze the diverse impacts of land transfer on rural revitalization as discussed in the literature, we employ a ‘goal–strategy–indicator–outcome’ analytical framework to conduct a meta-analysis and visual assessment of 131 cases drawn from 52 articles published over the past decade. We systematically explore the pathways by which land transfer impacts rural revitalization and validate the results using typical cases reported by the Ministry of Agriculture and Rural Affairs through Python 3.9 analysis. The findings reveal the following: (1) Land transfer generally exerts a positive impact on rural revitalization (81.7% of 107 cases). (2) It significantly boosts living standards (84% positive cases) and industrial prosperity (88.4% positive cases); rural cultural civilization shows 100% positive cases yet with statistically insignificant coefficients, while its impacts on ecological livability (60%) and effective governance (70.6%) are insignificant. (3) Among 12 indicators, those related to agricultural production and farmers’ livelihoods are positive, whereas those concerning rural ecology and governance are negative. This study indicates that land transfer plays a key role in the rural revitalization strategy, but the ecological impacts and governance challenges that it presents require ongoing attention and optimization at the policy level.

Purpose: To study the regulatory influence of microRNA-146a (miR-146a) on 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine (MPTP)-induced neuroinflammation in mice with Parkinson's disease (PD). Methods: Forty specific pathogen-free (SPF) male C57BL/6 mice were divided into 2 groups: normal control and PD groups. The 2 groups were each divided into 2 subgroups: miR-146a inhibitor and inhibitor control groups. The mRNA and protein expressions of miR-146a, interleukin-1 receptor- associated kinase-1 (IRAK-1) and P65-NF-κB were determined by quantitative real-time polymerase chain reaction (qRT-PCR) and immunoblot assay, respectively. Levels of interleukin (IL)-1, IL-6 and TNF-α were assayed by enzyme-linked immunosorbent assay (ELISA). Results: The level of expression of miR-146a was significantly and time-dependently increased in PD mice, relative to control (p < 0.05). In PD group, mRNA and protein expressions of IRAK-1 were markedly higher in miR-146a inhibitor group than in inhibitor control (p < 0.05). Protein expression of P65-NF-κB was significantly upregulated in brains of PD mice, relative to normal mice (p < 0.05). Moreover, IL-1, IL-6 and TNF-α levels were significantly higher in brains of PD mice than in control. Conclusion: These results show the involvement of miR-146a in the etiology of PD, and that its regulation of neuroinflammation occurs via inhibition of IRAK1 gene expression. This finding may be useful in the development of new anti-PD drugs based on miR-146a.

Comprehensive land prices for expropriation zones can effectively alleviate many conflicts in China’s land expropriation practices. This contributes to achieving sustainable development goals such as “SDG-10: Reduced Inequalities” and “ SDG-11: Sustainable Cities and Communities”. The reasonable delineation of expropriation zones and scientific calculation of zone prices have become crucial. This study used the Cangzhou urban area in Hebei Province, China, as a case study. By integrating the CA–Markov model, multiple linear regression model, coupling coordination degree model, relative development degree model, and GIS spatial analysis techniques, the study deeply analyzed the spatiotemporal coupling relationship between land use and comprehensive land prices for expropriation zones from 2009 to 2021. Furthermore, it simulated and forecasted the changes in land use, expropriation zones, and zone prices in 2027. The study yielded the following conclusions: (1) The changes in land use reflected land economic value, land resource condition and land location condition shifts, which formed an interactive feedback mechanism with the comprehensive land price for land expropriation zones. (2) Land use impacted zone distribution through the spatial distribution characteristics of construction land, with recent development zones in the central urban area primarily extending east and southeast due to planning and policies related to land use for construction. (3) The coupling coordination and relative developmental degree between land use degree and zone price gradually develop in a good direction. A linear relationship is observed among land economic value, land resource condition, and land location condition concerning the zone price. Based on this, the predicted adjustment ranges for zone prices from high to low in 2027 will be 2.6400 to 2.7210, 2.1900 to 2.2537, and 1.8300 to 1.9306 million CNY/hectare. This study provides a new method for studying comprehensive land prices for expropriation zones, supporting decision making.

Granulocyte colony-stimulating factor (G-CSF) can effectively improve body’s immunity. This study explored G-CSF’s role in dopaminergic neurons apoptosis in Parkinson’s disease mice model. In this study, Oxidopamine, also known as 6-hydroxydopamine (6-OHDA) drugs were used to establish mouse models, and 2,3,5-Triphenyltetrazolium chloride (TTC) measurement of brain nerve cell apoptosis and mouse motor function scores methods were used to analyze and clarify whether G-CSF’s role in inflammatory process is through regulating monocyte chemoattractant protein 1 (MCP-1) expression and T cell immune function. Meanwhile, neutrophil infiltration in apoptotic and surrounding areas was also assessed. Nerve cell apoptosis was significantly reduced After a single dose of G-CSF treatment in the model 24 h after successful modeling, compared with PBS control group (P <0.05). The motor function of mice in the G-CSF treatment group was significantly improved (P <0.05) on days 7 and 14. Moreover, the expressions of MCP-1, IL-10, TNF-α, and TGF-β were significantly decreased through therapeutic intervention, and inflammation was controlled (P < 0.05). The number of CD11b infiltration in the apoptotic area in the G-CSF group did not increase, suggesting that intervention did not reduce apoptosis of nerve cells. Bcl-2 expression in the treatment group was significantly higher than in the control group, and Bax expression was lower (P <0.05). In addition, the number of dopamine BrdU+ cells in the substantia nigra was significantly increased (P <0.05). G-CSF can thus promote bone marrow hematopoiesis, thereby stimulating endogenous nerve cell proliferation, resisting nerve damage in Parkinson’s mice, and promoting neuron regeneration to help preserve neuronal function in mice and improve prognosis.