Background: Entering old age is associated with various physical and psychological disabilities. Therefore, the aim of this study is to determine the effect of mindfulness-based stress reduction program on emotion regulation and sleep problems in depressed elderly. Methods: This study was a clinical trial conducted on 60 elderly individuals with depression using purposive sampling. These elderly were referred by geriatricians and were included in the study based on the inclusion criteria. The participants were randomly assigned to two groups: the Mindfulness-Based Stress Reduction (MBSR) group and the control group. Both groups completed the Geriatric Depression Scale (GDS), the Gratz and Roemer Emotion Regulation Questionnaire, and the Pittsburgh Sleep Quality Index before and after the intervention. The MBSR sessions were held for the experimental group in 8 sessions of 90 min each, once a week. Finally, all the data were analyzed using SPSS software version 26 through descriptive and analytical statistics such as mean and standard deviation, t-tests and mixed analysis of covariance (ANCOVA) with repeated measures. Results: The results showed that the MBSR intervention led to a significant reduction in depression symptoms (p < 0.001) and improvement in emotion regulation and sleep quality (p < 0.001) among the elderly participants with depression in the intervention group. Discussion: The results of this study showed that MBSR can be effective in reducing depression levels, improving emotion regulation, and sleep quality among depressed elderly individuals compared to the control group. Caregivers and psychotherapists of nursing homes can use care programs such as MBSR program to improve the physical and mental condition of the elderly. Trial registration: First Registration: 13/01/2022, Registration Number: IRCT20211118053099N1, Access: https://www.irct.ir/trial/61207.

The aim of this study was to scrutinize the E-learning readiness among the students of the Faculty of Health at Isfahan University of Medical Sciences during the Covid-19 pandemic. This study was conducted as a descriptive-analytic study on 165 the students of the Faculty of Health in Isfahan University of Medical Sciences in 2021. To examine the level of the participants' readiness for E-learning during the Covid-19 pandemic period, the questionnaire developed by Watkins et al, was administered. Finally, the data analysis was performed with SPSS₂₄ software. The results showed that the mean and standard deviation were 97.44 and 17.67, respectively. Only 1.2% of the participants had a low level of E-learning readiness. 27.9% were at the intermediate level and 70.9% were at the high level. Moreover, the results revealed that the participants had the highest degree of readiness in "Technology Access" and "Internet discussions" dimensions (0.79) and the lowest degree of readiness in "motivation" dimension (0.67). The results of this study indicated that the majority of the participants in this study had a high E-learning readiness, so the university can implement the virtual education. However, the students' learning motivation should be enhanced through providing the required infrastructure and holding training courses for the students specially the BA ones.

The aim of this study was to investigate the effectiveness of mindfulness-based stress reduction (MBSR) program on depression and physical problems in depressed elderly individuals. This randomized controlled trial was conducted on two groups of 30 depressed elderly individuals over 60 years old using purposive sampling. The GDS and the PE-PSI questionnaires were administered to both groups before and after the intervention. A standardized 8-week MBSR training program was held for the experimental group weekly for 1.5 hours. The results showed that between the beginning and 8 weeks of MBSR therapeutic intervention, the level of depression in the elderly individuals significantly decreased ( p < 0.001). However, significant improvements in changes in physical problems measured by PE-PSI were not found ( p > 0.05). This study provides preliminary evidence for the effectiveness of MBSR as a suitable treatment for the elderly individuals, which caregivers and psychologists in nursing homes can use to improve the mental well-being of the elderly individuals.

Background: This study investigated the impact of climate variables on the prevalence of malaria, a climate-sensitive infectious disease. Methods: A systematic review was conducted on articles published from Mar 2000 to Aug 2023 in Persian and English languages. Overall, 10,731 articles were retrieved, and 58 studies were included in the analysis. Results: Climate variables such as temperature, rainfall, and humidity play a significant role in predicting malaria outbreaks, with inconsistencies observed in different regions, including Iran. The study highlights the need for tailored preventive. Conclusion: Strategies and interventions to address the impact of climate change on malaria transmission. Enhanced health system resilience is essential to combat the anticipated rise in malaria cases in the future.

The utilization of synthetic dyes increases the risk to human health. Despite the progress of information on azo dyes, very little attention has been reported on toxicity assessment of anthraquinone dyes. Solvent Blue 35 (SB35) is one of the anthraquinone dyes likely to be encountered because of its increasing use in various industries. Whereas the design of laboratory tests is very expensive, in silico screening was used to predict the metabolic profile and toxicity effect of SB35. MetaTox software was used to predict the metabolites of phase I and II in two layers. Since airborne exposure has been considered, the pathways of inhalation and dermal absorption of SB35 were investigated through the SwissADME model based on the modified Lipinski’s rule of five. To predict the biological effect and toxicity of SB35 and each of the metabolites, PASS online software was used. Chemical activity was considered according to the probability of activation values (Pa) higher than the probability of inactivation values (Pi). N- dealkylation of SB35 was predicted in the first layer, while seven active compounds were obtained in the second layer from phases I and II reactions. Investigating the physicochemical properties of SB35 confirmed inhalation absorption for occupational exposure scenarios. All metabolites are absorbed from intestinal routes based on the RO5 rules. SB35 and their metabolites have an effective substrate role for the sub-type of CYP 450 enzymes. The toxicity effect of carcinogenicity for SB35 and mutagenicity for metabolites are predicted while confirmed with some biological effects. However, reproductive disorders are pointed with SB35 by probability higher than 70%. Virtual screening methods are efficient tools for creating cost-effective predictions in the hazard’s evaluation of SB35. However, a perspective view is suggested before decision-making for laboratory designing tests.