Study Design.: A systematic review and meta-analysis. Objective.: This study aims to compare pedicle screw accuracy, clinical outcomes, and complications between navigated and conventional techniques. Summary of Background Data.: In the last decades, intraoperative navigation has been introduced in spinal surgery to prevent risks and complications. Materials and Methods.: The search was executed on Cochrane Central Library, PubMed, and Scopus on April 30, 2023. Randomized controlled trials, prospective and retrospective studies that compared pedicle screw accuracy in the thoracic-lumbar-sacral segments, blood loss, operative time, hospital stay, intraoperative and postoperative revision of screws, neurological and systemic complications, Visual Analogue Scale (VAS), and Oswestry Disability Index (ODI) between navigated and freehand or fluoroscopy-assisted techniques were included in this study. The meta-analysis was performed using Review Manager software. Clinical outcomes were assessed as continuous outcomes with mean difference, while pedicle screw accuracy and complications were assessed as dichotomous outcomes with odds ratio, all with 95% CIs. The statistical significance of the results was fixed at P<0.05. Results.: This meta-analysis included 30 studies for a total of 17,911 patients and 24,600 pedicle screws. Statistically significant results in favor of the navigated technique were observed for the accuracy of pedicle screws (P=0.0001), hospital stay (P=0.0002), blood loss (P<0.0001), postoperative revision of pedicle screws (P<0.00001), and systemic complications (P=0.0008). In particular, the positioning of the screws was clinically acceptable in 96.2% of the navigated group and 94.2% with traditional techniques. No significant differences were found in VAS, ODI, and operative time between the two groups. Conclusion.: Navigated pedicle screw fixation has been demonstrated to be a safe and effective technique with high improvement in clinical outcomes and accuracy in patients undergoing spinal fusion compared with conventional techniques. Level of Evidence.: Level III.

Static radiographic alignment fails to capture the dynamic nature of joint behaviour during functional tasks. To address this, our study evaluated the relationship between Hip-Knee-Ankle angle (HKAA) and dynamic biomechanical variables (dynamic HKAA (dHKAA), via projection of hip, knee, and ankle joint centers onto the frontal plane, knee adduction moment (KAM), and knee abduction angle (KAA)), during gait and sit-to-stand tasks with and without arm assistance. A further objective was to examine the mediolateral center of pressure (COP ML) as a complementary parameter for assessing joint loading and frontal plane alignment. Twenty-two patients (mean age 67 ± 9 years, BMI 28.7 ± 3.4 kg/m²) with end-stage knee osteoarthritis scheduled for total knee arthroplasty were recruited. HKAA was extracted from full-length standing radiographs, while dynamic variables from 3D motion capture and force plates data. Associations between static and dynamic parameters were evaluated using correlation and linear regression analyses. dHKAA consistently exhibited stronger correlations with KAM and KAA than radiographic HKAA, particularly during gait loading response (ρ = 0.93; R² = 0.84, p < 0.01). Similar trends were observed in the other tasks, where HKAA showed limited associations. COP ML showed moderate correlations with KAM but none with dHKAA. These findings suggest that HKAA alone may not reliably capture functional joint loading, and that dHKAA provides a more comprehensive assessment of frontal plane knee behaviour. COP ML showed limited associations and should be cautiously interpreted in this context. These findings may enhance clinical assessments, surgical planning, and advancing-personalized, biomechanically driven intervention research.

Background/Objectives: Rotator cuff tears are a prevalent cause of shoulder pain and functional impairment. Full-thickness tears often require surgical intervention, but managing such injuries can be challenging, particularly when complete anatomical repair is unattainable. Bioinductive implants have emerged as an innovative adjunct to enhance tendon healing and regeneration. Methods: This case report details the partial repair of a full-thickness rotator cuff tear in a 66-year-old woman, augmented with a bioinductive implant. Postoperative recovery was monitored through clinical examinations, MRI, and kinematic analysis at 3 and 6 months. Results: The findings suggest that bioinductive implants may offer a promising strategy for managing complex rotator cuff tears, particularly when complete repair is not feasible. The patient reported improvement in function and pain reduction. Conclusions: The use of bioinductive implants showed promising results, promoting tendon regeneration and improving functional outcomes. Future research should explore patient selection criteria and the long-term effectiveness of this strategy.

Musculoskeletal tumors encompass a heterogeneous group of neoplasms that, owing to their location and aggressive nature, present significant therapeutic challenges. Within this context, embolization—a minimally invasive technique aimed at selectively occluding tumor-supplying blood vessels—is emerging as a promising complementary or, in certain instances, primary approach. Its potential to reduce tumor volume, control pain, and facilitate surgical intervention renders it an area of increasing clinical interest. This article explores the current role of embolization in treating diverse musculoskeletal tumors, analyzing available scientific evidence, clinical indications, procedural techniques, and potential complications. Available comparative evidence is most developed for preoperative embolization of hypervascular spinal tumors and metastatic lesions. Some systematic reviews and meta-analyses suggest a reduction in intraoperative blood loss, facilitation of surgical resection and improved pain palliation. Evidence concerning extra-spinal tumors, local tumor control, recurrence prevention, and selected benign lesions is more limited and is derived predominantly from small retrospective series. While complications are generally infrequent, they necessitate meticulous superselective catheterization and multidisciplinary planning to mitigate risks such as non-target embolization. Transarterial embolization has a selective, indication-dependent role in the multidisciplinary management of musculoskeletal tumors, particularly for preoperative devascularization of selected hypervascular lesions, promising improved patient outcomes.