Wen-Hung Twan

Dr. Wen-Hung Twan


Research Focus & Metrics

Academic Career Length

15Years (2012-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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8 June 2021 in Biosensors
Verified
Journal Article
Open access
PDF file
LYLiren Yeh
Liren Yeh
WCWei-Chin Chen
Wei-Chin Chen
HCHua-Yan Chan
Hua-Yan Chan
NLNan-Han Lu
Nan-Han Lu
CWChi-Yuan Wang
Chi-Yuan Wang
TCTai-Been Chen
Tai-Been Chen
Anesthesia assessment is most important during surgery. Anesthesiologists use electrocardiogram (ECG) signals to assess the patient’s condition and give appropriate medications. However, it is not easy to interpret the ECG signals. Even physicians with more than 10 years of clinical experience may still misjudge. Therefore, this study uses convolutional neural networks to classify ECG image types to assist in anesthesia assessment. The research uses Internet of Things (IoT) technology to develop ECG signal measurement prototypes. At the same time, it classifies signal types through deep neural networks, divided into QRS widening, sinus rhythm, ST depression, and ST elevation. Three models, ResNet, AlexNet, and SqueezeNet, are developed with 50% of the training set and test set. Finally, the accuracy and kappa statistics of ResNet, AlexNet, and SqueezeNet in ECG waveform classification were (0.97, 0.96), (0.96, 0.95), and (0.75, 0.67), respectively. This research shows that it is feasible to measure ECG in real time through IoT and then distinguish four types through deep neural network models. In the future, more types of ECG images will be added, which can improve the real-time classification practicality of the deep model.

19 October 2020 in Molecules
Verified
Journal Article
Open access
PDF file
SHShih Yen Hsu
Shih Yen Hsu
LYLiren Yeh
Liren Yeh
TCTai-Been Chen
Tai-Been Chen
WDWei-Chang Du
Wei-Chang Du
YHYung-Hui Huang
Yung-Hui Huang
HCHuei-Yung Chen
Huei-Yung Chen
Single photon emission computed tomography (SPECT) has been employed to detect Parkinson’s disease (PD). However, analysis of the SPECT PD images was mostly based on the region of interest (ROI) approach. Due to limited size of the ROI, especially in the multi-stage classification of PD, this study utilizes deep learning methods to establish a multiple stages classification model of PD. In the retrospective study, the 99mTc-TRODAT-1 was used for brain SPECT imaging. A total of 202 cases were collected, and five slices were selected for analysis from each subject. The total number of images was thus 1010. According to the Hoehn and Yahr Scale standards, all the cases were divided into healthy, early, middle, late four stages, and HYS I~V six stages. Deep learning is compared with five convolutional neural networks (CNNs). The input images included grayscale and pseudo color of two types. The training and validation sets were 70% and 30%. The accuracy, recall, precision, F-score, and Kappa values were used to evaluate the models’ performance. The best accuracy of the models based on grayscale and color images in four and six stages were 0.83 (AlexNet), 0.85 (VGG), 0.78 (DenseNet) and 0.78 (DenseNet).

27 November 2012 in Molecules
Verified
Journal Article
Open access
PDF file
WYWei-Hsuan Yen
Wei-Hsuan Yen
LHLi-Chung Hu
Li-Chung Hu
JSJui-Hsin Su
Jui-Hsin Su
MLMei-Chin Lu
Mei-Chin Lu
WTWen-Hung Twan
Wen-Hung Twan
Ping-Jyun SungPing-Jyun Sung
Ping-Jyun Sung
Two norcembranoidal diterpenes, 5-episinuleptolide acetate (1) and scabrolide D (2), were isolated from a Formosan octocoral identified as Sinularia sp. The structures of norcembranoids 1 and 2 were established by spectroscopic methods and by comparison of the spectral data with those of known analogues and 1 was proven to be a new natural product. Norcembranoid 1 was found to exhibit cytotoxicity toward a panel of tumor cells.

7 August 2023 in Healthcare
Verified
Journal Article
Open access
PDF file
JWJing-Zhe Wang
Jing-Zhe Wang
NLNan-Han Lu
Nan-Han Lu
WDWei-Chang Du
Wei-Chang Du
KLKuo-Ying Liu
Kuo-Ying Liu
SHShih Yen Hsu
Shih Yen Hsu
YHYung-Hui Huang
Yung-Hui Huang
This study focuses on overcoming challenges in classifying eye diseases using color fundus photographs by leveraging deep learning techniques, aiming to enhance early detection and diagnosis accuracy. We utilized a dataset of 6392 color fundus photographs across eight disease categories, which was later augmented to 17,766 images. Five well-known convolutional neural networks (CNNs)—efficientnetb0, mobilenetv2, shufflenet, resnet50, and resnet101—and a custom-built CNN were integrated and trained on this dataset. Image sizes were standardized, and model performance was evaluated via accuracy, Kappa coefficient, and precision metrics. Shufflenet and efficientnetb0demonstrated strong performances, while our custom 17-layer CNN outperformed all with an accuracy of 0.930 and a Kappa coefficient of 0.920. Furthermore, we found that the fusion of image features with classical machine learning classifiers increased the performance, with Logistic Regression showcasing the best results. Our study highlights the potential of AI and deep learning models in accurately classifying eye diseases and demonstrates the efficacy of custom-built models and the fusion of deep learning and classical methods. Future work should focus on validating these methods across larger datasets and assessing their real-world applicability.

3 March 2025 in Science of The Total Environment
Verified
Journal Article
Closed access
LTLi-Chun Tseng
Li-Chun Tseng
HCHong-Miao Chen
Hong-Miao Chen
CCChi Chou
Chi Chou
WTWen-Hung Twan
Wen-Hung Twan
YZYan-Ying Zhou
Yan-Ying Zhou
JHJiang-Shiou Hwang
Jiang-Shiou Hwang