Given the potential of polyphenols to mitigate neurodegenerative diseases (NDDs), this meta-analysis investigated whether clinical evidence supports the use of polyphenols for neuroprotection and as nutritional strategies in NDDs.

Based on the BERTopic model, this study analyzes 15,744 scientific papers in the field of functional agriculture from 1995 to 2024 to uncover core themes and evolutionary trends in global functional agriculture, and particularly focuses on revealing the developmental trajectory in China. The results indicate that global functional agriculture research is characterized by diverse themes and intensive study, forming a multi-topic cross-network centered on plant chemical extraction and agricultural soil research, with a focus on food nutrition, human health, and environmental protection. By contrast, China’s functional agriculture research demonstrates a more focused and in-depth approach, concentrating on functional food development and agricultural environmental protection themes, with notable growth trends in areas such as selenium-enriched products and resistant starch. Combined with China’s agricultural development environment, this study makes the following suggestions for the development of functional agriculture in China: (1) Promoting interdisciplinary cooperation between functional agriculture and other technologies. (2) Developing agricultural products with Chinese characteristics and forming Chinese functional agricultural product brands. (3) Utilizing smart farming technology to boost functional agriculture.

Polyphenols are a diverse group of plant-derived bioactives that have been investigated as multi-target candidates for the potential prevention and management of neurodegenerative diseases (NDDs). We conducted an integrated bibliometric and mechanistic scoping review covering 12 polyphenol classes and seven major NDDs using records from PubMed, Embase, the Cochrane Library, and Web of Science (1940–2024). Research landscapes and emerging themes were mapped using keyword co-occurrence, clustering analyses, and BERTopic modeling. Mechanistic evidence was synthesized across core pathways, including oxidative stress, neuroinflammation, proteostasis (amyloid/tau and α-synuclein), mitochondrial dysfunction, and cholinergic modulation, to link preclinical findings with clinical outcomes. Publication output increased markedly after 2000, with China and the United States contributing the most records. Four persistent hotspots were identified: (1) antioxidant and neuroprotective effects (e.g., resveratrol, curcumin); (2) anti-inflammatory activity and intracellular signaling; (3) cognition, aging, and sex-specific responses in clinical research; and (4) animal models of memory impairment. Clinically investigated interventions include epigallocatechin gallate, Ginkgo biloba extracts, olive/cocoa polyphenols, and flavonoid-rich mixtures; however, limited bioavailability and heterogeneous trial designs constrain the strength of effect estimates. Advances in delivery systems, computational screening, and precision nutrition may improve translation. Overall, polyphenols show multi-target neuroprotective potential, but larger and more standardized clinical trials are needed to support evidence-based nutritional strategies for NDD prevention and management.

随着全球人口的持续增长和人们对高质量生活的向往和追求, 农业生产方式正面临着新的转变和挑战. 关注农产品 “营养化, 功能化” 的功能农业 (Functional agriculture) 正逐渐受到中国乃至世界农业科学家的重视. 尽管功能农业概念的提出仅有16年, 但世界范围内关于功能微量营养素的研究已有上百年的历史. 本研究发现国内外功能农业领域研究呈稳步上升趋势. 国外相关研究主要集中在功能食品精准调控和加工等方向, 而国内在土壤功能性成分评估, 功能食品加工与封装技术等方面表现出较高的关注. 本综述研究对于了解功能农业领域的当前研究现状, 不足之处以及未来研究热点具有重要的启示意义.