842 Background: GAT regimen has being tested as NC in LABC patients (pts), based on its efficacy in metastatic disease (Sanchez-Rovira et al. Oncology 2001; 15(2): 44–47). Methods: Newly diagnosed stage IIB-III non-inflammatory BC pts were enrolled in this phase II trial. 2 pathological complete responses (pCR) were needed among the first 29 pts to continue accrual (Simon’s test, 95% probability of 10% pCR). Doxorubicin (A) 40 mg/m2 was given on day 1 as a 15 minutes IV infusion; gemcitabine (G) 2000 mg/m2 and paclitaxel (T) 150 mg/m2 were given as a 60 minutes and 3 hours IV infusion respectively on day 2. Cycles (Cy) were administered biweekly for a total of 6 courses. The study was approved by appropriate ethics committees; informed consent was obtained for all pts. Results: 46 pts have been enrolled, median age was 49.6 years (range 30.1–72.5) and median tumour size 6 cm (range 3.0–14.0). 4 (8.7%) and 42 (91.3%) pts presented with stage IIB and III disease, respectively. 56.5% of pts were premenopausa...

Background: This study explored whether opinions about the government’s role in addressing the COVID-19 pandemic vary based on demographic characteristics and racial beliefs. We hypothesized that opinions about the United States (U.S.) government’s response to COVID-19 would differ based on an individual’s characteristics such as age, race, and racial beliefs. Methods: We utilized an Inter-University Consortium for Political and Social Research dataset to examine differences in opinion regarding the government’s pandemic response, considering personal characteristics and racial beliefs. Descriptive statistics depicted respondents’ characteristics, and a Chi-square test for independence assessed whether differences emerged based on racial attitude, self-reported racial identity, sex, income, education, and age. Logistic regression analyses were conducted to independently determine which characteristics were associated with differences in evaluating the government’s pandemic response. Results: The sample consisted of 1028 respondents: 47.5% male and 52.5% female. Overall, the group viewed the government unfavorably, with only 40% reporting that the government responded correctly and 54% believing the government is almost always wasteful and inefficient. Hispanics or Latinos were more likely to view the government as wasteful or inefficient, while more Whites rated the government’s pandemic response as appropriate. Individuals who believed that racial discrimination is the main reason why many Black people cannot get ahead generally regarded the government’s pandemic response more favorably. Only 5% deemed the government’s response excessive. Being Black, younger, and female was associated with the view that racial discrimination is the main reason why many Black people cannot get ahead. Individuals who felt this way viewed the government unfavorably by almost a 2:1 ratio. Conclusions: A majority of U.S. residents do not believe the government responded correctly to the pandemic and more than half viewed the government as wasteful and inefficient. Differences emerged by ethnicity and racial attitudes, with individuals of color holding more negative views of the government’s response. Understanding this perspective can help develop messaging and strategies that resonate with communities where racial and minority groups live.

Prostate cancer kills more Puerto Rican men than cancers of the lung, trachea and bronchus. Physical activity has an inconsistent relationship with prostate cancer. It is not clear what the relationship between body habitus and physical activity is among non-Whites population. The underlying hypothesis of this epidemiological research is that excess body adiposity and sedentary lifestyles are independent risk factors for prostate cancer mortality in Puerto Rican men. The specific aims of this proposal are (1) to investigate the association between anthropometric measurements or changes in body weight and prostate cancer mortality, and (2) to study the relationship between physical activity and prostate cancer mortality. This study uses an observational longitudinal design with a random sample of 9,824 Puerto Rican men aged 35- 79 years at baseline (1964) who were part of the Puerto Rico Heart Health Program (PRHHP). Using a survival analysis approach and a total follow-up time of approximately 35 years we plan to examine the relationship of the above risk factors with prostate cancer mortality. There continues to be health disparities in prostate cancer incidence and mortality in minorities and our findings will improve our knowledge of the relationship between prostate cancer and other lifestyles.