Open abdomen therapy has become a commonly used strategy in the treatment of serious abdominal conditions. A potential major complication is the development of enteroatmospheric fistula, as it has been linked to increased mortality and morbidity
1,2. Vacuum-assisted wound closure and mesh-mediated fascial traction has been demonstrated to be a safe technique when applied correctly
3,4. To reduce the risk of fistula development, the use of an inert film (visceral protective layer, VPL) between the vulnerable intestines and dressing material/mesh might be beneficial
4,5. This study aimed to define the effect of VPL application on the incidence of enteroatmospheric fistula during open abdomen therapy based on a large registry data set.