The prevalence, incidence and mortality rates of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease are gradually increasing. New approaches are being developed to manage the progression and treatment of neurodegenerative diseases. Catechins, polyphenolic compounds, are key compounds that demonstrate therapeutic effects with their properties such as antioxidant, anti-inflammatory, anti-apoptotic properties in the prevention and treatment of neurodegenerative diseases. The therapeutic effects of catechins have been exhaustively studied in human and animal models. Catechins can have anti-inflammatory effects by suppressing inflammatory pathways and cytokines, as well as antioxidant effects such as chelating metal ions and scavenging radicals. They might reduce phosphorylation of tau proteins, aggregation of amyloid-beta and apoptotic proteins release. They can also decrease alpha-synuclein accumulation and increase dopamine levels. With all these effects, they can have an effect on neurodegenerative diseases. This review points to the potential mechanisms of catechins in neurodegenerative diseases, based on their findings in the literature review.

The aim of the study was to establish an in vitro Parkinson’s disease (PD) model and to investigate the cell viability, anti-inflammatory, anti-apoptotic and neuroprotective effects of catechin and...

Diet may play an important role in the development of asymptomatic hyperuricemia (ASH) and gouty arthritis (GOUT). However, the association between dietary factors and hyperuricemia remains unclear. Serum uric acid levels are affected by dietary factors. This study aimed to evaluate the correlation of uric acid levels with biochemical parameters and dietary factors in individuals with ASH and GOUT. This study was conducted in 145 individuals with ASH and GOUT. General characteristics of individuals were collected via face-to-face interviews. Food frequency questionnaire was used to obtain energy, macro- and micronutrients intakes. Biochemical parameters were obtained from patient files. The incidence of gout was higher in men comparing to women. Individuals in the GOUT group consumed more alcohol and higher serum levels of vitamin B₁₂, C-reactive protein (CRP), triglyceride, and uric acid. Individuals in the GOUT group had higher intakes of energy, protein, carbohydrate, fat, fructose, vitamin C, and vitamin B₁₂. Triglyceride, uric acid, CRP, vitamin B₁₂, and homeostatic model assessment of insulin resistance were found to be affected by high uric acid levels. Dietary factors can pose a risk for health problems in addition to GOUT and ASH, such as cardiovascular disease, diabetes, and obesity.

Daytime Sleepiness, Body Mass Index, and Physical Activity Levels Among University Undergraduate Students: Do They Affect Sleep Quality? - Cyprus Journal of Medical Sciences

Bilberry (Vaccinium myrtillus L.) is a fruit with high polyphenolic content and rich in anthocyanins. Due to its strong antioxidant capacity, it has potential effects in improving human health and reducing the risk of diseases. In addition to its antioxidant effect, it also possesses potential anti-inflammatory, anti-carcinogenic, anti-angiogenic, anti-proliferative, anti-atherogenic, anti-microbial, anti-diabetic, anti-lipidemic, neuroprotective, anti-metastatic, anti-radical effects, as well as preventing lipid oxidation, reducing oxidative stress and improving eye health. Bilberry consumption can potentially protect against and reduce the risks of chronic inflammation, dyslipidemia, hyperglycemia, increased oxidative stress, cardiovascular diseases, diabetes, dementia, and other age-related diseases and cancer. This review focuses on the potential mechanisms of action of bilberry in cancer.

A Cross-Sectional Study of Hypertension Prevalence, Awareness, Treatment, Ratios under Control and Related Factors in Turkish Cypriot Individuals Living in North Cyprus - Cyprus Journal of Medical Sciences