Mahmoud El Safadi

Dr. Mahmoud El Safadi

Chemistry, United Arab Emirates University, Al Ain, United Arab Emirates
orcid

Research Focus & Metrics

Academic Career Length

10Years (2017-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 October 2017 in Inorganica Chimica Acta
Verified
Journal Article
Open access
Mahmoud El SafadiMahmoud El Safadi
Mahmoud El Safadi
MBMohan Bhadbhade
Mohan Bhadbhade
RSRonald Shimmon
Ronald Shimmon
ABAnthony T. Baker
Anthony T. Baker
AMAndrew Mcdonagh
Andrew Mcdonagh

4 September 2024 in Pesticide Biochemistry and Physiology
Verified
Journal Article
Closed access
Mahmoud El SafadiMahmoud El Safadi
Mahmoud El Safadi
QAQurat-Ul-Ain Ahmad
Qurat-Ul-Ain Ahmad
MMMuhammad Majeebullah
Muhammad Majeebullah
AAAdnan Ali
Adnan Ali
AAAhmedA Alemam
AhmedA Alemam
ASAhmad Mohammad Salamatullah
Ahmad Mohammad Salamatullah

30 July 2024 in Pesticide Biochemistry and Physiology
Verified
Journal Article
Closed access
ZPZhongtian Peng
Zhongtian Peng
HEHenry Edwards
Henry Edwards
WMWarda Mustfa
Warda Mustfa
Mahmoud El SafadiMahmoud El Safadi
Mahmoud El Safadi
STShahaba Tehreem
Shahaba Tehreem
HHHasooba Hira
Hasooba Hira

5 September 2024 in Molecules
Verified
Journal Article
Open access
PDF file
Mahmoud El SafadiMahmoud El Safadi
Mahmoud El Safadi
KWKatie Wilson
Katie Wilson
ISIndigo Jan Strudwicke
Indigo Jan Strudwicke
MOMegan L. O'Mara
Megan L. O'Mara
Mohan M. BhadbhadeMohan M. Bhadbhade
Mohan M. Bhadbhade
AMAndrew Mcdonagh
Andrew Mcdonagh
The accumulation of iron in dopaminergic neurons can cause oxidative stress and dopaminergic neuron degeneration. Iron chelation therapy may reduce dopaminergic neurodegeneration, but chelators should be targeted towards dopaminergic cells. In this work, two series of compounds based on 8-hydroxyquinoline and deferiprone, iron chelators that have amphetamine-like structures, have been designed, synthesized and characterized. Each of these compounds chelated iron ions in aqueous solution. The hydroxyquinoline-based compounds exhibited stronger iron-binding constants than those of the deferiprone derivatives. The hydroxyquinoline-based compounds also exhibited greater free radical scavenging activities compared to the deferiprone derivatives. Molecular dynamics simulations showed that the hydroxyquinoline-based compounds generally bound well within human dopamine transporter cavities. Thus, these compounds are excellent candidates for future exploration as drugs against diseases that are affected by iron-induced dopaminergic neuron damage, such as Parkinson’s disease.

16 January 2026 in Neurochemistry International
Verified
Journal Article
Closed access
KZKang Zhang
Kang Zhang
KAKiran Amir
Kiran Amir
AMArifa Mehreen
Arifa Mehreen
Mahmoud El SafadiMahmoud El Safadi
Mahmoud El Safadi
SZSaadiya Zia
Saadiya Zia
HHHesham M. Hassan
Hesham M. Hassan