In the search for alternative cementitious materials, the alkali activation of aluminosilicates has been found to be a mechanically effective binder. Among precursors, metakaolin is most frequently used, with a primary source, kaolin, distributed globally in varying compositions. This variability may indicate potential compositional limitations for the large-scale production of such binders. Thus, four types of commercial calcined clays, activated under identical conditions, were evaluated, and their physicochemical characteristics were correlated with the mechanical properties of the resulting binder. Different characterization methods were used for the raw material and for each alkali-activated system. Anhydrous metakaolin was assessed through particle size distribution, specific surface area, zeta potential, vitreous phases, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), amorphism, and pozzolanic activity. The pastes were evaluated in the fresh state through apparent activation energy progression and isothermal conduction calorimetry, and in the hardened state through compressive strength and dilatometry. Compressive strength values ranged from 7 to 42 MPa. From these results, a mathematical model was developed to estimate mechanical performance based on key variables, specifically amorphism, the pozzolanic index, and the silica-to-alumina ratio. This model allows for performance predictions without the need to prepare additional pastes. Interestingly, it was found that while some systems displayed low initial reactivity, their relative reactivity over time increased more significantly than those with higher early-stage reactivity, suggesting their potential for reconsideration in long-term applications.