Background: Glaucoma is a leading cause of irreversible blindness worldwide, necessitating precise management strategies tailored to individual patient characteristics. Artificial intelligence (AI) holds promise in revolutionizing the approach to glaucoma care by providing personalized interventions. Aim: This review explores the current landscape of AI applications in the personalized management of glaucoma patients, highlighting advancements, challenges, and future directions. Methods: A systematic search of electronic databases, including PubMed, Scopus, and Web of Science, was conducted to identify relevant studies published up to 2024. Studies exploring the use of AI techniques in personalized management strategies for glaucoma patients were included. Results: The review identified diverse AI applications in glaucoma management, ranging from early detection and diagnosis to treatment optimization and prognosis prediction. Machine learning algorithms, particularly deep learning models, demonstrated high accuracy in diagnosing glaucoma from various imaging modalities such as optical coherence tomography (OCT) and visual field tests. AI-driven risk stratification tools facilitated personalized treatment decisions by integrating patient-specific data with predictive analytics, enhancing therapeutic outcomes while minimizing adverse effects. Moreover, AI-based teleophthalmology platforms enabled remote monitoring and timely intervention, improving patient access to specialized care. Conclusions: Integrating AI technologies in the personalized management of glaucoma patients holds immense potential for optimizing clinical decision-making, enhancing treatment efficacy, and mitigating disease progression. However, challenges such as data heterogeneity, model interpretability, and regulatory concerns warrant further investigation. Future research should focus on refining AI algorithms, validating their clinical utility through large-scale prospective studies, and ensuring seamless integration into routine clinical practice to realize the full benefits of personalized glaucoma care.