Glaucoma is a group of eye diseases which can cause vision loss by damaging the optic nerve. Early glaucoma detection is key to preventing vision loss yet there is a lack of noticeable early symptoms. Colour fundus photography allows the optic disc (OD) to be examined to diagnose glaucoma. Typically, this is done by measuring the vertical cup-to-disc ratio (CDR); however, glaucoma is characterised by thinning of the rim asymmetrically in the inferior-superior-temporal-nasal regions in increasing order. Automatic delineation of the OD features has potential to improve glaucoma management by allowing for this asymmetry to be considered in the measurements. Here, we propose a new deep-learning-based method to segment the OD and optic cup (OC). The core of the proposed method is DenseNet with a fully-convolutional network, whose symmetric U-shaped architecture allows pixel-wise classification. The predicted OD and OC boundaries are then used to estimate the CDR on two axes for glaucoma diagnosis. We assess the proposed method’s performance using a large retinal colour fundus dataset, outperforming state-of-the-art segmentation methods. Furthermore, we generalise our method to segment four fundus datasets from different devices without further training, outperforming the state-of-the-art on two and achieving comparable results on the remaining two.

Glaucoma is one of the common causes of blindness worldwide. It leads to deterioration in vision and quality of life if it is not cured early. This paper addresses the feasibility of developing an automatic feature learning technique for detecting glaucoma in colored retinal fundus images using a deep learning method. A fully automated system based on convolutional neural network (CNN) is developed to distinguish between normal and glaucomatous patterns for diagnostic decisions. Unlike traditional methods where the optic disc features are handcrafted, the features are extracted automatically from the raw images by CNN and fed to the SVM classifier to classify the images into normal or abnormal. We demonstrate an accuracy, specificity and sensitivity of 88.2%, 90.8%, and 85%, respectively which compared favorably to the-state-of-the-art but at considerably lower computational cost. The obtained preliminary results clearly demonstrate that the proposed deep learning method is promising in automatic diagnosis of glaucoma.

Intrusion detection systems built on artificial intelligence (AI) are presented as latent mechanisms for actively detecting fresh attacks over a complex network. The authors used a qualitative method for analysing and evaluating the performance of network intrusion detection system (NIDS) in a systematic way. However, their approach has limitations as it only identifies gaps by analysing and summarising data comparisons without considering quantitative measurements of NIDS's performance. The authors provide a detailed discussion of various deep learning (DL) methods and explain data intrusion networks based on an infrastructure of networks and attack types. The authors’ main contribution is a systematic review that utilises meta‐analysis to provide an in‐depth analysis of DL and traditional machine learning (ML) in notable recent works. The authors assess validation methodologies and clarify recent trends related to dataset intrusion, detected attacks, and classification tasks to improve traditional ML and DL in NIDS‐based publications. Finally, challenges and future developments are discussed to pose new risks and complexities for network security.

Glaucoma is the leading cause of irreversible blindness worldwide. It is a heterogeneous group of conditions with a common optic neuropathy and associated loss of peripheral vision. Both over and under-diagnosis carry high costs in terms of healthcare spending and preventable blindness. The characteristic clinical feature of glaucoma is asymmetrical optic nerve rim narrowing, which is difficult for humans to quantify reliably. Strategies to improve and automate optic disc assessment are therefore needed to prevent sight loss. We developed a novel glaucoma detection algorithm that segments and analyses colour photographs to quantify optic nerve rim consistency around the whole disc at 15-degree intervals. This provides a profile of the cup/disc ratio, in contrast to the vertical cup/disc ratio in common use. We introduce a spatial probabilistic model, to account for the optic nerve shape, we then use this model to derive a disc deformation index and a decision rule for glaucoma. We tested our algorithm on two separate image datasets (ORIGA and RIM-ONE). The spatial algorithm accurately distinguished glaucomatous and healthy discs on internal and external validation (AUROC 99.6% and 91.0% respectively). It achieves this using a dataset 100-times smaller than that required for deep learning algorithms, is flexible to the type of cup and disc segmentation (automated or semi-automated), utilises images with missing data, and is correlated with the disc size (p = 0.02) and the rim-to-disc at the narrowest rim (p<0.001, in external validation). The spatial probabilistic algorithm is highly accurate, highly data efficient and it extends to any imaging hardware in which the boundaries of cup and disc can be segmented, thus making the algorithm particularly applicable to research into disease mechanisms, and also glaucoma screening in low resource settings.