Biodegradable medical implants have fundamentally transformed the field of biomedical engineering by providing sustainable and biocompatible alternatives that obviate the need for secondary surgical removal and facilitate endogenous tissue regeneration. This comprehensive review systematically evaluates recent advancements in biodegradable implants utilized across a spectrum of medical applications, including internal medicine, surgical interventions, and medical devices. The developments discussed herein signify substantial progress in material synthesis, characterization, and processing techniques, effectively addressing critical challenges associated with the integration of biodegradable devices into medical implants. Although biodegradable medical implants promise advanced patient care, widespread clinical translation is hindered by inconsistent degradation rates mismatched with healing timelines, insufficient load‐bearing strength, and potential inflammatory or toxic by‐products. Additionally, most studies exhibit application‐material imbalances, inadequate in vivo validation, and poorly controlled degradation behavior. Future efforts must clarify degradation mechanisms and treat materials as therapeutic agents. By synthesizing recent findings and highlighting critical gaps, this review provides valuable insights to guide innovation in biodegradable implant technologies, ultimately enhancing clinical outcomes and accelerating regenerative medicine's progress. Addressing these challenges is crucial for realizing their full clinical potential.

Antifreeze agents play a critical role in various fields including tissue engineering, gene therapy, therapeutic protein production, and transplantation. Commonly used antifreeze agents such as DMSO and other organic substances are known to have cytotoxic effects. Antifreeze proteins sourced from cold-adapted organisms offer a promising solution by inhibiting ice crystal formation; however, their effectiveness is hindered by a dynamic ice-shaping (DIS) effect and thermal hysteresis (TH) properties. In response to these limitations, antifreeze peptides (AFPs) have been developed as alternatives to antifreeze proteins, providing similar antifreeze properties without the associated drawbacks. This review explores the methods for acquiring AFPs, with a particular emphasis on chemical synthesis. It aims to offer valuable insights and practical implications to drive the realm of sub-zero storage.

Enzymatic resolution of α-trifluoromethylated amines via kinetic resolution (KR), dynamic kinetic resolution (DKR) employing CALB-Pd/Al₂O₃, and a one-pot sequential process of KR/DKR/KR was investigated comparatively for the first time. Although CALB-catalyzed KR of α-trifluoromethylated amines with substituents of methyl (1a), isopropyl (1c), phenyl (1d) and benzyl group (1e) can provide good stereoselectivity factors E from 31 to >200 respectively, DKR and sequential process of KR/DKR/KR possess better practical application potential because of the higher conversion (62%–84%) and the similar enantiomeric excesses (90%–99%). The enantiopreference and inversion for the α-trifluoromethylated amines displayed by CALB were observed and explained by docking modes. Namely, for 1,1,1-trifluoro-2-propylamine (1a), the product amide with R-configuration was obtained, and the enantiopreference was converted to S for the amines (1b–1e) with substituents larger than methyl group. The catalysts recycle, and scale-up experiments were demonstrated successfully. All these results indicated the high efficiency and green feature of this enzymatic process, and its application significance.