Background/Objectives: Periprosthetic joint infection (PJI) is one of the most common complications after joint replacement. Two-stage revision remains the standard of care in chronic infections. The aim of this systematic review was to investigate the outcomes, complications, and eradication rates of two-stage revision surgery to treat PJI of the shoulder, elbow, hip, and knee. Methods: A total of 36 studies were included. Patient demographics, follow-up, the visual analog scale (VAS) for pain, the Constant–Murley score (CMS) for shoulder, the Harris Hip Score (HHS) for hip, the Knee Society Score (KSS) for knee, the range of motion (ROM), number and types of complications, and eradication rate were recorded. Results: A total of 2484 patients were identified, of whom 145, 29, 1269, and 1041 underwent two-stage revision surgery for shoulder, elbow, hip, and knee infections, respectively. The overall mean follow-up was 5.7 ± 4.5 years. The overall mean time of re-implantation was 20.8 ± 21.3 weeks. The most common causative bacteria were Cutibacterium acnes (32.7%) for shoulder, Methicillin-Sensitive Staphylococcus aureus (44.4%) for elbow, and Staphylococcus coagulase negative (CNS) (31.3% and 23%) for hip and knee infection, respectively. The mean overall preoperative VAS score was 6.7 ± 2.3, while, postoperatively, the mean score was 4.5 ± 2.7 (p < 0.001). A total of 2059 out of 2484 patients (82.9%) experienced eradication. Conclusions: Two-stage revision is an effective procedure to treat PJI with an overall eradication rate of 83%. A significant recovery of functionality and a decrease in residual pain can be achieved after surgery. Aseptic loosening and re-infection were the most common complications in shoulder and hip infections. Death rate was high in knee infections.

Objectives: Osteoarthritis (OA) of the medial compartment in varus knee is a common degenerative condition. High tibial osteotomy (HTO) has been recognized as a primary joint-sparing procedure. The aim of this systematic review was to investigate functional and radiological outcomes, complications, and the progression of knee OA in patients undergoing medial opening wedge HTO. Methods: A total of 18 studies were included. Patients’ demographics, Knee Injury and Osteoarthritis Outcome Score (KOOS), number and types of complications, conversion in arthroplasty surgery rate, survival rate, and radiological evaluation were recorded. Results: A total of 2683 patients were evaluated. The frequency-weighted mean follow-up was 168.6 ± 54.6 months. The mean preoperative KOOS score was 46.5 ± 19, while postoperatively the mean score was 66.4 ± 22.9 (p < 0.001). The pre- and postoperative mTFA angle was −5.7° ± 2.8°, and 1.4° ± 2.4°, respectively; with a statistically significant improvement (p = 0.002). A total of 12.5% of patients had a conversion to a total knee arthroplasty and 1.5% had a conversion to unicompartmental knee arthroplasty, while 1.3% of the patients had a revision surgery unrelated to arthroplasty. The survival rate after 10 years was 86.3%. The nonunion rate was 1.3% and the infection rate was 0.9%. Conclusions: Patients who underwent medial opening wedge HTO achieved a significant correction of mTFA associated with an improvement in functional outcomes. An 86% survivorship rate at 10 years was observed, while a 14% conversion rate to knee arthroplasty for OA progression was reported after a mean follow-up of 14 years.