Background: Alzheimer’s disease is a progressive neurodegenerative disease characterized by structural changes in the brain, including hippocampal atrophy, cortical thinning, amyloid plaques, and tau tangles. Due to the aging of the global population, the burden of Alzheimer’s disease is expected to increase, making the exploration of non-pharmacological interventions, such as physical exercise, an urgent priority. Results: There is emerging evidence that regular physical exercise may mitigate the structural and functional declines associated with Alzheimer’s disease. The underlying mechanisms, however, remain poorly understood. Gut–brain axis research is a promising area for further investigation. This system involves bidirectional communication between the gut microbiome and the brain. According to recent studies, the gut microbiome may influence brain health through modulating neuroinflammation, producing neuroactive compounds, and altering metabolic processes. Exercise has been shown to alter the composition of the gut microbiome, potentially impacting brain structure and function. In this review, we aim to synthesize current research on the relationship between physical exercise, structural brain changes in Alzheimer’s disease, and the gut–brain axis. Conclusions: In this study, we will investigate whether changes in the gut microbiome induced by physical exercise can mediate its neuroprotective effects, offering new insights into the prevention and treatment of Alzheimer’s disease. By integrating findings from neuroimaging studies, clinical trials, and microbiome research, this review will highlight potential mechanisms. It will also identify key gaps in the literature. This will pave the way for future research directions.

The aims of this cross-sectional study were (i) to determine the association of educational level attained with cognitive impairment and (ii) to investigate the mediating effect of different self-report physical activity (PA) patterns in a large sample of older Chileans. A sample of 1571 older adults from the National Chilean Survey (2016–2017) was included. The educational level attained, PA levels, mode of commuting, sedentary time, and leisure-time PA were self-reported through validated questionnaires. Cognitive impairment was determined by Mini-Mental State Examination (modified version). Association between educational level attained and cognitive impairment was examined using logistic regression models. Counterfactual mediation models were used to test the mediating effect of self-reported PA patterns. A lower educational level was consistently associated with higher odds of cognitive impairment (OR range 2.846 to 2.266, all p < 0.001), while leisure-time PA was the only PA pattern that partially mediated this association (proportion mediated 8.0%). In conclusion, leisure-time PA was the solely PA pattern that partially mediated the association between the educational level and cognitive impairment. The rest self-reported PA patterns did not modify this association.

It is estimated that one in 100 children worldwide has been diagnosed with autism spectrum disorder (ASD). Children with ASD frequently suffer from gut dysbiosis and gastrointestinal issues, findings which possibly play a role in the pathogenesis and/or severity of their condition. Physical activity may have a positive effect on the composition of the intestinal microbiota of healthy adults. However, the effect of exercise both on the gastrointestinal problems and intestinal microbiota (and thus possibly on ASD) itself in affected children is unknown. In terms of understanding the physiopathology and manifestations of ASD, analysis of the gut–brain axis holds some promise. Here, we discuss the physiopathology of ASD in terms of genetics and microbiota composition, and how physical activity may be a promising non-pharmaceutical approach to improve ASD-related symptoms.

Street workout (SW) is an urban sport based on calisthenic exercises. Injury profiles and risk factors are widely explored in various sport disciplines. However, because of the lack of research in SW, injury profiles have not yet been established. To investigate the characteristics and prevalence of injuries and variables that may increase these odds in SW practitioners. Case-control study; Level of evidence, 4. An electronic survey was conducted between September 2018 and March 2019 in order to obtain practitioner information, physical activity level, training characteristics, and injury information of SW practitioners. Responses from 93 practitioners were eligible for analysis. Univariate and multivariate binary logistic regression analyses were used to examine the association among several variables and the presence of injury in the past 12 months based on odds ratios (ORs). Overall, 62.4% of the 93 participants reported an injury in the previous 12 months, and tendinopathy was the most reported diagnosis (31.0% of injured practitioners). High injury frequency was reported in the shoulder (23.0%) and back (upper and mid) (18.4%). Overtraining was the most reported perception of cause of injury (56.9%). Most injured practitioners (20.7%) performed freestyle exercises before the injury, followed by upper body exercises. A history of previous injuries (OR, 4.078; P = .005) and the middle and higher tertiles of vigorous physical activity (OR, 4.370; P = .015 and OR, 5.634; P = .003, respectively) were associated with a higher odds of injury. In SW, the shoulder and back (upper and mid) were the most injured body parts, with tendinopathy being the most frequent diagnosis. Overtraining was typically reported as the perceived cause of injury, with freestyle and upper limb exercises the most performed exercises when injured. A history of previous injuries, along with vigorous physical activity, was found to augment the odds of injury. More research is needed to corroborate our findings, along with increased knowledge about SW practice and injuries.

In several sports, morphological differences exist when comparing training status. However, these are less known in novel urban sports such as Street Workout (SW). This study compares the morphological characteristics between untrained (novice) and trained (experienced) SW athletes. Thirty-seven male Street workout practitioners from Viña del Mar (Chile) participated. Anthropometric, body composition, and somatotype data were assessed and compared according to the training experience. We found that trained SW athletes had a higher flexed and tensed arm perimeter (+4.4 %, p=0.038), lower hips perimeter (-4.8 %, p=0.041), narrower biiliocristal breadth (-3.2 %, p=0.035), lesser sum of 6 skinfolds (-40.8 %, p<0.001), and a lower endomorphic component (p<0.001) than untrained SW athletes. The proportionality analysis revealed that trained athletes had significantly higher upper body perimeters and lower skinfolds than untrained athletes. In addition, trained participants had higher percentages of the whole-body (+6.5 %, p<0.001) and upper limb muscle mass (+1.1 %; <0.001), and lower fat mass percentage (-7.9 %, p<0.001) and fat mass (-6.9 kg, p<0.001). In conclusion, similar to other sports, morphological differences exist in SW according to the training status, suggesting that morphology is associated with training experience. Further studies using DEXA should corroborate our findings and, in turn, determine the relevance of morphology in SW performance.