Lung cancer remains the leading cause of cancer death in the United States, underscoring the critical need to optimize treatment strategies. Compared to conventional treatments such as surgical resection, radiotherapy, chemotherapy, and immunotherapy, targeted therapy stands out for its higher selectivity and minimal adverse effects. Among these, epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are the most widely used in targeted therapy for non-small-cell lung cancer (NSCLC). In our paper, we will conduct a comprehensive review of current literature on EGFR TKIs to contribute to advancements in molecular genomics and the treatment of lung cancer.

Single-direction thoracoscopic lobectomy: a step in the right direction

Background: Lye ingestion or other esophageal trauma may require surgical reconstruction. The hypopharyngeal anastomosis during esophageal reconstruction is a technically demanding procedure with many nuances in approach. Patients often have a challenging post-operative course, and few regain the ability to tolerate a normal diet. Case presentation: We describe a case series of three patients (2 colon interpositions and 1 gastric pull-up) who underwent esophageal reconstruction with a hypopharyngeal anastomosis at our institution from years 2017 to 2024, then review the literature. Conclusions: We recommend a multidisciplinary team approach with otolaryngology and/or general surgery for the neck dissection and preparation of the conduit. For the hypopharyngeal anastomosis, we recommend a two-layer, interrupted suture method to the left, lateral piriform sinus along with careful laryngeal nerve preservation. Patients require close follow-up for endoscopic therapy to treat the often-inevitable dysphagia after surgery. All three patients survived and had improved swallow function after surgery.