Background: Osteoarthritis is a chronic joint disease that affects dogs and humans alike, with nonsteroidal anti‐inflammatory drugs (NSAIDs) being the primary drug treatment for pain relief. This study hypothesised that pentoxifylline could be a potent therapeutic option for canine osteoarthritis, offering superior benefits compared to meloxicam. The study aimed to mitigate inflammation and degeneration, safeguard joint integrity, and assess pentoxifylline's potential as a safer and more effective alternative to NSAIDs in osteoarthritis management. Methods: 12 dogs with stifle osteoarthritis were divided into two groups: meloxicam (0.1 mg/kg, subcutaneous) and pentoxifylline (10 mg/kg, intramuscular). Clinical, radiological and biochemical examinations were conducted on days 0, 15, 30 and 60. Results: The pain scores were significantly lower in the meloxicam group on days 30 and 60 ( p < 0.05). However, both groups had similar scores for other clinical evaluations ( p > 0.05). Serum C‐reactive protein (CRP) levels were lower in the pentoxifylline group on days 15 and 30, and serum IL‐1β levels were lower on days 15, 30 and 60 ( p < 0.05). Moreover, cartilage oligomeric matrix protein (COMP) and bone alkaline phosphatase (bALP) levels in the pentoxifylline group showed a significant reduction on day 15 ( p < 0.05). Pentoxifylline reduced osteocalcin in serum and hyaluronic acid concentrations in synovial fluid on days 15 and 30 ( p < 0.05). However, the level of cross‐linked C‐telopeptide of type 2 collagen in urine significantly decreased following meloxicam treatment. Conclusion: Meloxicam relieves pain by protecting joint cartilage, while even low doses of pentoxifylline enhance joint perfusion and combat inflammation. Future research should explore higher pentoxifylline doses and its potential synergy with NSAIDs for superior osteoarthritis management.

Effect of intra-articular administration of autologous PRP and activated PRP on inflammatory mediators in dogs with osteoarthritis | K Parlak, M Arican | Agricultural Journals

Gastrointestinal foreign bodies are common in animals and may present with various clinical manifestations depending on the location, severity, and duration of the obstruction. Linear foreign body (LFB) obstructions are more common in cats compared to dogs, and the foreign body causing the obstruction is usually thread or threaded needle. In our study, it was aimed to determine the radiography and the localization of the obstruction in the diagnosis of LFB in cats, to investigate the operative treatment options and their effects on the prognosis. The study material consisted of 12 cats of different breeds, ages, and genders, who were referred with the suspicion of foreign body with acute/chronic vomiting and anorexia. After the identification of the foreign body causing the obstruction, treatment was planned considering its localization, severity and duration of pathology. All foreign bodies were removed surgical procedures. The most common finding was the plication in the intestines. Four cats died in the postoperative period. As a result, early and rapid diagnosis in LFB positively affects the prognosis. Intestinal perforations caused by LFB and infection due to bacterial translocation are inevitable in delayed cases. Another issue to be considered is that in cats that show symptoms of gastrointestinal system origin, it is extremely important to carry out a detailed examination of the mouth. In addition, it is thought that trying to pull out the LFBs that protruding out from the anus increases the risk of perforation in the intestines.

This study aim to evaluate the modified Glasgow Coma Scale (mGCS) and Animal Trauma Triage (ATT) scores, labo- ratory variables, and prognostic features of trauma-induced endothelial glycocalyx injury in cats with head trauma. Twenty-five cats with head trauma and 10 healthy cats were evaluated in this study. The enzyme-linked immunosorbent assay (ELISA) method was used to measure the levels of syndecan-1 and thrombomodulin in the serum of the 25 cats with head trauma (within 48 hours) and the 10 healthy cats. In addition, mGCS scores, ATT scores, laboratory values, syndecan-1 and thrombomodulin levels were compared between the cats that survived following treatment and the cats that did not survive despite treatment. Syndecan-1 and thrombomodulin levels were not statistically different between healthy cats and cats with head trauma. In the cats with head trauma, the mGCS scoring system was found to be more sensitive than the ATT scoring system. In conclusion, syndecan-1 and thrombomodulin levels did not yield statistically significant results in the cats with head trauma. VREDNOTENJE SISTEMA OCENJEVANJA TRAVME IN POŠKODB ENDOTELIJSKEGA GLIKOKALIKSA PRI MAČKAH S POŠKODBO GLAVE Izvleček: Namen te študije je bil ovrednotiti spremenjeno glasgowsko lestvico kome (angl. Glasgow Coma Scale, GCS) in ocene ATT (Animal Trauma Triage), laboratorijske spremenljivke in prognostične značilnosti s travmo povzročene poškodbe endotelijskega glikokaliksa pri mačkah s poškodbo glave. V študijo je bilo vključenih 25 mačk s poškodbo glave in 10 zdravih mačk. Ravni sindekana-1 in trombomodulina v serumu 25 mačk s poškodbo glave (v 48 urah) in 10 zdravih mačk smo merili z encimsko imunoadsorpcijsko preiskavo (ELISA). Ocene mGCS, ocene ATT, laboratorijske vrednosti ter ravni sindekana-1 in trombomodulina smo primerjali med mačkami, ki so po zdravljenju preživele, in mačkami, ki kljub zdravljenju niso preživele. Vrednosti sindekana-1 in trombomodulina se med zdravimi mačkami in mačkami s poškodbo glave niso statistično razlikova- le. Pri mačkah s poškodbo glave se je sistem točkovanja mCGS izkazal za občutljivejšega od sistema točkovanja ATT. Zaklju- čili smo, da vrednosti sindekana-1 in trombomodulina pri mačkah s poškodbo glave niso statistično pomembne. Ključne besede: triaža poškodb živali; mačka; poškodba glave; spremenjena glasgowska lestvica kome; endotelijski glikokaliks

The aim of this study was to evaluate the effectiveness of imaging techniques (video-otoscopy-VO, radiography-RTG, computed tomography-CT) in diagnosing ear diseases in cats and dogs. Seven cats and thirteen dogs diagnosed with ear diseases were used for the research. Clinical examination, VO, RTG and CT were performed. Three (42.9%) unilateral otitis externa (OE), three (42.9%) unilateral otitis media (OM), and one (14.2%) bilateral otitis media (OM) with OE were diagnosed in 7 cats. Five (38.4%) unilateral OE, one (7.7%) unilateral OM, four (30.8%) bilateral OE, and three (23.1%) bilateral OM with OE were diagnosed in 13 dogs. All diagnostic methods were determined to be highly efficient for the specified diagnosis. VO and RTG were confirmed as sufficiently effective for the diagnosis of OE. OE plays a major role in the etiopathogenesis of OM, and for this reason, RTG and CT are required diagnostic methods for this condition.