Ensemble Learning (EL) has been used for almost ten years to classify heart diseases, but it is still difficult to grasp how the “black boxes”, or non-interpretable models, behave inside. Predicting heart disease is crucial to healthcare, since it allows for prompt diagnosis and treatment of the patient’s true state. Nonetheless, it is still difficult to forecast illness with any degree of accuracy. In this study, we have suggested a framework for the prediction of heart disease based on Explainable artificial intelligence (XAI)-based hybrid Ensemble Learning (EL) models, such as LightBoost and XGBoost algorithms. The main goals are to build predictive models and apply SHAP (SHapley Additive expPlanations) and LIME (Local Interpretable Model-agnostic Explanations) analysis to improve the interpretability of the models. We carefully construct our systems and test different hybrid ensemble learning algorithms to determine which model is best for heart disease prediction (HDP). The approach promotes interpretability and transparency when examining these widespread health issues. By combining hybrid Ensemble learning models with XAI, the important factors and risk signals that underpin the co-occurrence of heart disease are made visible. The accuracy, precision, and recall of such models were used to evaluate their efficacy. This study highlights how crucial it is for healthcare models to be transparent and recommends the inclusion of XAI to improve interpretability and medical decisionmaking.

Background/Objectives: Brain tumors are among the most aggressive diseases, significantly contributing to human mortality. Typically, the classification of brain tumors is performed through a biopsy, which is often delayed until brain surgery is necessary. An automated image classification technique is crucial for accelerating diagnosis, reducing the need for invasive procedures and minimizing the risk of manual diagnostic errors being made by radiologists. Additionally, the security of sensitive MRI images remains a major concern, with robust encryption methods required to protect patient data from unauthorized access and breaches in Medical Internet of Things (MIoT) systems. Methods: This study proposes a secure and automated MRI image classification system that integrates chaotic and Arnold encryption techniques with hybrid deep learning models using VGG16 and a deep neural network (DNN). The methodology ensures MRI image confidentiality while enabling the accurate classification of brain tumors and not compromising performance. Results: The proposed system demonstrated a high classification performance under both encryption scenarios. For chaotic encryption, it achieved an accuracy of 93.75%, precision of 94.38%, recall of 93.75%, and an F-score of 93.67%. For Arnold encryption, the model attained an accuracy of 94.1%, precision of 96.9%, recall of 94.1%, and an F-score of 96.6%. These results indicate that encrypted images can still be effectively classified, ensuring both security and diagnostic accuracy. Conclusions: The proposed hybrid deep learning approach provides a secure, accurate, and efficient solution for brain tumor detection in MIoT-based healthcare applications. By encrypting MRI images before classification, the system ensures patient data confidentiality while maintaining high diagnostic performance. This approach can empower radiologists and healthcare professionals worldwide, enabling early and secure brain tumor diagnosis without the need for invasive procedures.

Background: Recently, drug repositioning has received considerable attention for its advantage to pharmaceutical industries in drug development. Artificial intelligence techniques have greatly enhanced drug reproduction by discovering therapeutic drug profiles, side effects, and new target proteins. However, as the number of drugs increases, their targets and enormous interactions produce imbalanced data that might not be preferable as an input to a prediction model immediately.Methods: This paper proposes a novel scheme for predicting drug–target interactions (DTIs) based on drug chemical structures and protein sequences. The drug Morgan fingerprint, drug constitutional descriptors, protein amino acid composition, and protein dipeptide composition were employed to extract the drugs and protein’s characteristics. Then, the proposed approach for extracting negative samples using a support vector machine one-class classifier was developed to tackle the imbalanced data problem feature sets from the drug–target dataset. Negative and positive samplings were constructed and fed into different prediction algorithms to identify DTIs. A 10-fold CV validation test procedure was applied to assess the predictability of the proposed method, in addition to the study of the effectiveness of the chemical and physical features in the evaluation and discovery of the drug–target interactions.Results: Our experimental model outperformed existing techniques concerning the curve for receiver operating characteristic (AUC), accuracy, precision, recall F-score, mean square error, and MCC. The results obtained by the AdaBoost classifier enhanced prediction accuracy by 2.74%, precision by 1.98%, AUC by 1.14%, F-score by 3.53%, and MCC by 4.54% over existing methods.

Classifying Electroencephalogram (EEG) signals for wheelchair navigation presents significant challenges due to high dimensionality, noise, outliers, and class imbalances. This study proposes an optimized classification framework that evaluates ten machine learning (ML) models, emphasizing ensemble methods, feature selection (FS), and outlier utilization. The dataset, comprising 2869 samples and 141 features, was processed using Recursive Feature Elimination (RFE) and correlation thresholds (CTs), achieving a peak accuracy of 69% with Extra Trees after FS. Notably, training on outlier-only data yielded even higher accuracy (Extra Trees: 82%), underscoring the value of outliers in enhancing class separability. Receiver Operating Characteristic–Precision Recall (ROC-PR) curve analysis confirmed that Extra Trees achieved a ROC AUC (Area Under Curve) of 0.92 and PR AUC of 0.82 for the best-classified movement command, while other models exhibited lower precision-recall (PR) balance. This approach, complemented by explainability techniques, offers a robust solution for EEG-based wheelchair control systems and paves the way for interpretable brain-computer interfaces (BCIs).

Air pollution has exceeded the anticipated safety limit and addressing this issue is crucial for sustainability, particularly in countries with high pollution levels. So, monitoring and forecasting air quality is essential for sustainable urban development. Therefore, this paper presents multiclass classification using two feature selection techniques, namely Sequential Forward Selection (SFS) and filtering, both with different machine learning and ensemble techniques, to predict air quality and make sure that the most relevant features are included in datasets for air quality determination. The results of the considered framework reveal that the SFS technique provides superior performance compared to filter feature selection (FFS) with different ML methods, including the AdaBoost Classifier, the Extra Tree Classifier, Random Forest (RF), and the Bagging Classifier, for efficiently determining the Air Quality Index (AQI). These models’ performances are assessed using predetermined performance metrics. The AdaBoost Classifier model with FFS has the lowest accuracy, while the RF model with SFS achieves the highest accuracy, at 78.4% and 99.99%, respectively. Based on the raw dataset, it was noted that the F1-score, recall, and precision values of the RF model with SFS are 99.96%, 99.97%, and 99.98%, respectively. Therefore, the experimental results undoubtedly show the supremacy, reliability, and robustness of the proposed approach in determining the AQI effectively.