Thiol-disulfide homeostasis (TDH), one of the most important antioxidants, is involved in the non-enzymatic removal of reactive oxygen molecules in the body and is one of the many methods to measure the level of oxidative stress (OS). In the present study, TDH is investigated in adolescent depression, and its relationship to clinical variables is examined. Thirty-two (50.0%) patients diagnosed with major depressive disorder (MDD) and without psychotropic drug use and 32 (50.0%) healthy controls were included in the present study. The subjects MDD and control groups were between 13 and 18 years old. Participants completed the DSM-5 Level-2 scales for depression and irritability. A colorimetric method proposed by Erel and Neselioglu was used to analyze the TDH parameters of serum samples. Biochemical analyses of samples from the MDD and control groups showed significant differences between the groups in native thiol (SH) levels (P = .002), disulfide (SS) levels (P = .021), disulfide/total thiol (SS/ToSH) (P = .009), and disulfide/native thiol (SS/SH) (P = .003) levels. Analysis of receiver operating characteristic showed that the area under the curve values with “acceptable discrimination potential” for the TDH parameters were significantly able to discriminate individuals with MDD from healthy controls. Thiol-disulfide homeostasis, one of the OS parameters, was found to be impaired in adolescents with depression. Our results suggest that TDH may contribute to the etiopathogenesis of adolescent MDD and that TDH may be a novel approach to assess OS in adolescent depression.

Aylin Deniz Uzun, ?ermin Yalın Sapmaz, Masum Öztürk, Hasan Kandemir. Clin Psychopharmacol Neurosci 2019;17:556-8. https://doi.org/10.9758/cpn.2019.17.4.556

Accumulating literature predicts that more individuals will begin to experience distress related to climate crisis , so studies on how clinicians can respond to such distress seem important. However, a review of the literature on interventions for eco-anxiety suggests that research is limited and existing studies have weak empirical foundations. Despite the limited literature, we aimed to build a picture of approaches that mental health professionals can use to make informed choices about eco-anxiety intervention. This review aims to provide an understanding of interventions to reduce eco-anxiety by summarising empirical studies and conceptual interventions in this area. Psychoanalytic approaches, grief-focused therapies, group therapies, existential therapies, cognitive behavioral therapy, acceptance and commitment therapy, and art-focused therapies are among the intervention methods that can be used in clients with eco-anxiety. In addition, holistic approaches such as ecotherapy, encouraging pro-environmental behaviors, and supporting self-care and resilience-building strategies are recommended in the eco-anxiety approach.

Background/Objectives: Attention-Deficit/Hyperactivity Disorder (ADHD) is associated with an increased risk of obesity and disordered eating behaviors. This study compared weight status and eating behaviors among drug-naïve ADHD children, those on stimulant monotherapy, those on combined stimulant and antipsychotic treatment, and healthy controls. Methods: This cross-sectional study included 547 children aged 6–12 years from four Turkish provinces: 361 with ADHD (152 drug-naïve, 156 on stimulants, and 53 on combined therapy), and 186 healthy controls. Anthropometric measurements, psychiatric assessments, and eating behavior evaluations were conducted using standardized tools. Results: Drug-naïve ADHD children had the highest obesity rate (13.8%), while those on stimulant monotherapy had the lowest (4.5%) compared to controls. Combined treatment group obesity rates were similar to controls (7.5% vs. 8.6%). The drug-naïve and combined treatment groups showed increased food approach behavior and desire to drink, with the combined treatment group also showing increased emotional overeating. Conclusions: This study reveals a complex relationship between ADHD, its pharmacological management, and the risk of obesity. Stimulant monotherapy may mitigate the risk of obesity, while combined stimulant and antipsychotic treatment may lead to problematic eating behaviors. These findings emphasize the importance of monitoring weight status and eating behaviors in ADHD children, especially those receiving pharmacological interventions.