The demand for minimally invasive body contouring procedures, particularly for gluteal augmentation, has grown significantly. This study evaluates the morphologic and rheological properties of four commercially available hyaluronic acid (HA) fillers used for body contouring and explores their clinical implications. Critical parameters such as storage modulus (G′), loss modulus (G″), complex modulus (G*), and damping factor (tan δ) were measured using oscillatory rheological tests to assess each filler’s elasticity, viscosity, and viscoelastic profile. Scanning Electron Microscopy (SEM) was performed to analyze the microstructure of the fillers, providing insights into their microscopic architecture. The results showed differences in mechanical properties and viscoelastic behavior among the fillers. These variations suggest that the choice of filler may need to be tailored to specific body contouring requirements. Understanding these differences is crucial for achieving the best clinical results and patient satisfaction, helping professionals select the most suitable filler for each case.

This article describes a technique for gluteal augmentation using cross-linked hyaluronic acid (HA) filler, with a focus on long-term patient follow-up. The rising demand for buttock enhancement driven by esthetic preferences has led to the exploration of minimally invasive alternatives to traditional surgical methods. Ultrasound imaging was utilised to evaluate the presence and distribution of HA filler over time. The patients reported satisfactory aesthetic improvements, with mild transient side effects. The findings highlight the technique’s effectiveness in achieving enhanced gluteal contour with a minimal volume of filler, demonstrating both safety and durability in the long term. This innovative approach may serve as a valuable option in aesthetic practises focused on body contouring.

Facial aging is primarily characterized by the loss and disorganization of the dermal extracellular matrix (ECM), particularly collagen. Injectable biostimulators, such as calcium hydroxyapatite (CaHA), represent a vital non-surgical strategy to counteract these changes by inducing neocollagenesis. This 90-day clinical trial was designed to comparatively evaluate the efficacy of a novel regenerative solution (RS) diluent, formulated to potentially enhance the biostimulatory effects of standard CaHA (STIIM product), against a conventional diluent (control) for the treatment of facial laxity. Twenty-one subjects (N = 21) were randomized to receive CaHA diluted with either RS or control formulation. Efficacy was assessed using histological analysis (collagen I area percentage), ultrasound (US) for dermal density, and clinical laxity scoring. Histological analysis, although limited by a small subsample size (N = 3), showed qualitative and exploratory evidence of collagen remodeling in both groups. However, the RS group showed enhanced dermal thickening via US (15% increase vs. 5% control, p-value = 0.012), and improvement in clinical laxity. Furthermore, histological findings, including Picrosirius red staining, indicated that the RS group resulted in qualitatively greater ECM organization and more robust type I collagen fibers compared to the control. The novel regenerative solution is safe and demonstrates enhanced neocollagenesis and clinical efficacy over the conventional formulation, validating its potential as a diluent for CaHA for optimized facial rejuvenation.

The report investigates hand rejuvenation using a novel dermal filler based on calcium hydroxyapatite. Hands undergo aging due to environmental factors and age-related changes. We present a case report of a patient who received applications of the product on the dorsum of the hand, exhibiting visible improvement in volume and reduced visibility of veins and tendons. Aesthetic evaluation indicates a 'very much improved' outcome, both for the physician and the patient. This report highlights the promising application of the novel dermal filler for hand rejuvenation.