Stefano De Francesco

Mr. Stefano De Francesco

orcid

Research Focus & Metrics

Academic Career Length

4Years (2023-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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17 January 2025 in Neuroscience & Biobehavioral Reviews
Verified
Journal Article
Closed access
SSSimona Scaini
Simona Scaini
SDSimon Davies
Simon Davies
SFStefano De Francesco
Stefano De Francesco
APAlessio Pelucchi
Alessio Pelucchi
SRSofia Rubino
Sofia Rubino
MBMarco Battaglia
Marco Battaglia

2 August 2023 in Autism Research
Verified
Journal Article
Open access
SFStefano De Francesco
Stefano De Francesco
LMLuisa Morello
Luisa Morello
MFMariachiara Fioravanti
Mariachiara Fioravanti
CCCristina Cassaro
Cristina Cassaro
SGSilvia Grazioli
Silvia Grazioli
ACAlessandro Crippa
Alessandro Crippa
It is still unclear whether and to what extent the motor difficulties are specific to autism. This study aimed to determine whether a multimodal assessment of motor skills could accurately discriminate autistic children from attention‐deficit/hyperactivity disorder (ADHD) and typically developing (TD) peers. Seventy‐five children, aged 7–13, equally divided into three groups, were assessed with the developmental coordination disorder questionnaire (DCDQ), the movement assessment battery for children 2 (MABC2), the sensorimotor subtests of NEPSY‐II, and the kinematic analysis of a reach‐to‐drop task. Principal component analysis (PCA) on DCDQ subscales revealed one factor—Caregiver Report—, whereas MABC2/NEPSY‐II scores identified three factors—namely, Object Interception and Balance, Motor Imitation, and Fine‐Motor Skills—. Lastly, PCA on kinematic variables identified four factors: PC1, loaded by the parameters of velocity and acceleration throughout the task, PC2 and PC3 involved the temporal parameters of the two submovements, and PC4 accounted for the wrist inclination at ball drop. When comparing autistic and TD children, Caregiver Report and Motor Imitation factors predicted membership with 87.2% of accuracy. In the model comparing ADHD and TD groups, Caregiver Report and Fine‐Motor Skills predicted membership with an accuracy of 73.5%. In the last model, the Object Interception and Balance factor differentiated autistic children from ADHD with an accuracy of 73.5%. In line with our previous findings, kinematics did not differentiate school‐aged autistic children from ADHD and TD peers. The present findings show that specific motor profiles in autism and ADHD can be isolated with a multimodal investigation of motor skills.

28 May 2025 in Applied Sciences
Verified
Journal Article
Open access
PDF file
GGGaia De Giuli
Gaia De Giuli
CACecilia Amico
Cecilia Amico
SFStefano De Francesco
Stefano De Francesco
LGLudovica Giani
Ludovica Giani
GTGulsah Tuzun
Gulsah Tuzun
SSSimona Scaini
Simona Scaini
Cognitive Disengagement Syndrome (CDS) is a clinical construct characterized by symptoms such as excessive daydreaming, mental confusion, slowed behavior, and reduced cognitive and motor activity. Increasing evidence suggests a potential overlap between CDS and Emotional Dysregulation (ED), a transdiagnostic construct associated with difficulties in regulating emotional responses. This narrative review synthesizes current empirical findings and theoretical perspectives on the co-occurrence of CDS and ED, with a particular focus on insights provided by behavioral genetics—especially twin studies. We describe the core principles and models used in twin research and evaluate how they have been applied to disentangle genetic and environmental contributions to these phenotypes and their overlap. While some studies support a shared etiology between CDS and ED, particularly through non-shared environmental influences, research in this area remains limited and conceptually fragmented. The review identifies critical knowledge gaps, including the lack of longitudinal studies, inconsistent definitions of ED, and limited exploration of developmental trajectories. We argue that future twin studies are essential for clarifying these unresolved issues. Nonetheless, limitations include the scarcity of twin-based studies directly examining the CDS–ED association and methodological inconsistencies across the existing literature.

11 August 2025 in Methods and Protocols
Verified
Journal Article
Open access
PDF file
SSSimona Scaini
Simona Scaini
SFStefano De Francesco
Stefano De Francesco
LGLudovica Giani
Ludovica Giani
MBMarco Battaglia
Marco Battaglia
EMEmanuela Medda
Emanuela Medda
CFCorrado Fagnani
Corrado Fagnani
Data on the genetic and environmental factors underlying the co-occurrence of Cognitive Disengagement Syndrome (CDS), Attention Deficit Hyperactivity Disorder (ADHD), and Emotional Dysregulation (ED) are limited. This study aimed to explore the nature of the associations between CDS, ADHD with ED, and to assess the role of shared etiological factors in explaining their comorbidity. We analyzed a sample of 400 Italian twin pairs aged 8–18, from Northern Italy and enrolled in the Italian Twin Registry. Bivariate genetic analyses were conducted using parent-rated CBCL scores for CDS, ADHD, and ED. For both CDS–ED and ADHD–ED associations, the best-fitting models were Cholesky AE models (−2LL = −849.167 and −339.030, respectively; p > 0.05), suggesting that the covariation was mainly due to additive genetic factors (CDS–ED—A = 0.81, 95% CI [0.66–0.95]; ADHD–ED—A = 0.86, 95% CI [0.75–0.95]). More than half of the genes were shown to be shared among the phenotypes. Non-shared environmental contributions were smaller (CDS–ED—E = 0.19, 95% CI [0.05–0.34]; ADHD–ED—E = 0.14, 95% CI [0.05–0.25]), indicating interrelated but distinct constructs. Despite some limitations, particularly the exclusive use of the CBCL, findings highlight the importance of monitoring ED symptoms in individuals with CDS or ADHD, and vice versa.

17 May 2024 in Preprints.org
Verified
Preprint
Open access
PDF file
SSSimona Scaini
Simona Scaini
SGSilvia Grazioli
Silvia Grazioli
LGLudovica Giani
Ludovica Giani
BFBarbara Forresi
Barbara Forresi
SFStefano De Francesco
Stefano De Francesco
MCMarcella Caputi
Marcella Caputi
There is evidence that the tendency to adopt a particular pattern of causal inference, known as attributional style, is likely to be associated with specific pattern of psychopathology among youth. This study aims to assess preliminary psychometric properties of the Italian Children’s Attributional Style Questionnaire-Revised (CASQ-R) and to explore the presence of any subgroups of children and early adolescents from the general population who might exhibit internally homogeneous and externally heterogeneous attributional styles, through cluster analyses, delving also potential sociodemographic and clinical differences among the identified clusters of attributional styles. A sample of 337 children was recruited and their attributional styles and depressive symptoms were analyzed. Four distinct clusters emerged using the six CASQ-R subscales in a multivariate finite mixture model. In particular, high levels of depressive symptoms were reported by children showing high scores in all the negative attributional subscales (globality, internality and stability) and medium scores in all the positive attributional subscales. Conversely, low levels of depressive symptoms were reported by children showing medium-to-high scores in the positive attributional subscales and low-to-medium scores in the negative attributional subscales. The identified clusters shed light on distinct patterns associated with depressive symptoms, offering potential insights for targeted interventions.

27 August 2025 in Children
Verified
Journal Article
Open access
PDF file
LGLudovica Giani
Ludovica Giani
SFStefano De Francesco
Stefano De Francesco
CACecilia Amico
Cecilia Amico
GGGaia De Giuli
Gaia De Giuli
MCMarcella Caputi
Marcella Caputi
SSSimona Scaini
Simona Scaini
Background/Objectives: Cognitive Disengagement Syndrome (CDS) is a clinical condition primarily characterized by inattention, hypoactivity, and mind-wandering, which has not yet been recognized as an official diagnostic category. Although there are overlaps between CDS and ADHD, evidence supports the semi-independence of CDS from the ADHD-Inattentive subtype. Importantly, while the impact of ADHD on parenting styles has been studied, no previous research has investigated the potential influence of CDS difficulties on parenting behaviors. Both CDS and ADHD are associated with internalizing and externalizing symptoms, which are influenced by negative parenting styles. The severity of ADHD is known to predict the use of dysfunctional parenting patterns; however, no studies have yet investigated how CDS difficulties might affect parenting styles. Due to the similarities between CDS and ADHD, it is reasonable to hypothesize a similar relationship. This study aims to examine the potential mediating role of parenting styles—both negative and positive—in the relationship between CDS difficulties and internalizing and externalizing symptoms. Methods: The sample is composed of 369 Italian school-aged children (9.38 ± 2.34 years old). Parents reported on their children’s psychopathology, CDS difficulties, and their own parenting strategies. Results: Analyses conducted using Hayes’ PROCESS tool indicated that only negative parenting styles partially mediated the relationship between CDS difficulties and parent-reported youth anxiety, depression, and oppositional defiant disorder. Conclusions: These findings highlight the importance of interventions aimed at both addressing CDS in children and improving parenting strategies to enhance youth psychopathological outcomes.