Microgrippers are typical microelectromechanical systems (MEMS) that are widely used for micromanipulation and microassembly in both biological and micromanufacturing fields. This paper presents the design, modelling, fabrication and experimental testing of an electrothermal microgripper based on a ‘hot and cold arm’ actuator design that is suitable for the deformability characterisation of human red blood cells (RBCs). The analysis of the mechanical properties of human RBCs is of great interest in the field of medicine as pathological alterations in the deformability characteristics of RBCs have been linked to a number of diseases. The study of the microgripper’s steady-state performance is initially carried out by the development of a lumped analytical model, followed by a numerical model established in CoventorWare^® (Coventor, Inc., Cary, NC, USA) using multiphysics finite element analysis. Both analytical and numerical models are based on an electothermomechanical analysis, and take into account the internal heat generation due to the applied potential, as well as conduction heat losses through both the anchor pads and the air gap to the substrate. The models are used to investigate key factors of the actuator’s performance including temperature distribution, deflection and stresses based on an elastic analysis of structures. Results show that analytical and numerical values for temperature and deflection are in good agreement. The analytical and computational models are then validated experimentally using a polysilicon microgripper fabricated by the standard surface micromachining process, PolyMUMPs™ (Durham, NC, USA). The microgripper’s actuation is characterised at atmospheric pressure by optical microscopy studies. Experimental results for the deflection of the microgripper arm tips are found to be in good agreement with the analytical and numerical results, with process-induced variations and the non-linear temperature dependence of the material properties accounting for the slight discrepancies observed. The microgripper is shown to actuate to a maximum opening displacement of 9 $\mathsf{\mu }$ m at an applied voltage of 3 V, thus being in line with the design requirement of an approximate opening of 8 $\mathsf{\mu }$ m for securing and characterising a RBC.

Microelectromechanical systems (MEMS) have established themselves within various fields dominated by high-precision micromanipulation, with the most distinguished sectors being the microassembly, micromanufacturing and biomedical ones. This paper presents a horizontal electrothermally actuated ‘hot and cold arm’ microgripper design to be used for the deformability study of human red blood cells (RBCs). In this study, the width and layer composition of the cold arm are varied to investigate the effects of dimensional and material variation of the cold arm on the resulting temperature distribution, and ultimately on the achieved lateral displacement at the microgripper arm tips. The cold arm widths investigated are 14 $\mathsf{\mu }$ m, 30 $\mathsf{\mu }$ m, 55 $\mathsf{\mu }$ m, 70 $\mathsf{\mu }$ m and 100 $\mathsf{\mu }$ m. A gold layer with a thin chromium adhesion promoter layer is deposited on the top surface of each of these cold arms to study its effect on the performance of the microgripper. The resultant ten microgripper design variants are fabricated using a commercially available MEMS fabrication technology known as a silicon-on-insulator multi-user MEMS process (SOIMUMPs)™. This process results in an overhanging 25 $\mathsf{\mu }$ m thick single crystal silicon microgripper structure having a low aspect ratio (width:thickness) value compared to surface micromachined structures where structural thicknesses are of the order of 2 $\mathsf{\mu }$ m. Finite element analysis was used to numerically model the microgripper structures and coupled electrothermomechanical simulations were implemented in CoventorWare ${}^{\circledR }$ . The numerical simulations took into account the temperature dependency of the coefficient of thermal expansion, the thermal conductivity and the electrical conductivity properties in order to achieve more reliable results. The fabricated microgrippers were actuated under atmospheric pressure and the experimental results achieved through optical microscopy studies conformed with those predicted by the numerical models. The gap opening and the temperature rise at the cell gripping zone were also compared for the different microgripper structures in this work, with the aim of identifying an optimal microgripper design for the deformability characterisation of RBCs.

A novel polymer-on-metal hip joint prosthesis design that makes use of uni-directional articulations was developed and tested in this work. The new implant was tested using two polymer variants, virgin ultra-high molecular weight polyethylene (UHMWPE), and Vitamin E-infused highly crosslinked polyethylene (VEHXPE). The degrees of freedom of the ball-and-socket are reproduced by three cylindrical orthogonally-aligned articulations. This unconventional design leverages on the molecular orientation hardening mechanisms of the polyethylene and increased contact area to minimize wear. An experimental hip joint simulator was used to compare the gravimetric wear of the conventional ball-on-socket and the new implant. The new prosthesis including UHMWPE components produced a 78% reduction in wear, whereas the new prosthesis with VEHXPE components produced a 100% reduction in wear, as no measurable wear was detected. Machining marks on the acetabular cups of the new prosthesis were retained for both polyethylene variants, further demonstrating the low levels of wear exhibited by the new implants. Both polyethylene materials produced particles in the range of 0.1-1.0 μm, which are the most biologically active. Nonetheless, the extremely low wear rates are likely to induce minimal osteolysis effects. Furthermore, the novel design also offers an increase of more than 24% in the range of motion in flexion/extension when compared to a dual-mobility hip implant. A prototype of the prosthesis was implanted into a Thiel-embalmed human cadaver during a mock-surgery, which demonstrated high resistance to dislocation and the possibility of performing a figure of four position.