Korean Circulation Journal 대한심장학회지 순환기 Kocabas R. Korean Circ J. 2023 Jan;53:e12. https://doi.org/10.4070/kcj.2022.0282

Objective: Conflicting data are available in literature regarding the effects of vitamin D (VitD) supplementation diet on lipid panel. Therefore, we had the purpose to evaluate the effects of VitD supplementation on lipid panel by a controlled experimental study, and those of VitD supplementation on oxidative stress index (OSI) and paraoxonase-1 (PON1) values in healthy and hypercholesterolemic male rabbits. Methods: Thirty New Zealand rabbits were randomly separated into control, VD, HC+VD and HC groups. Control and VD groups were fed with standard chow, whereas HC+VD and HC groups were fed with 0.5% cholesterol chow a period of 8 weeks. During this period, VD and HC+VD groups were orally administered with 300 IU/kg/day VitD. Results: The increase in serum total cholesterol (TC) and OSI level of HC group were significant compared to those in HC+VD group. Decreases in serum HDL-cholesterol (HDL-C) and TC levels of VD group were significant within the groups. Conclusion: Without any doubt it is important that applied VitD level should be in the ideal range for healthy living. However, it is also necessary to increase the serum HDL-C level (and hence PON1), which is decreases as a result of VitD supplementation. Therefore, we believe that during VitD supplementation, regular physical activity should be performed to increases serum HDL-C.

Aims: Obsessive compulsive disorder (OCD) is a heterogeneous disorder characterized by obsessions and compulsions. Despite the studies, etiopathogenesis is not fully understood. Pharmacological and psychosocial interventions in OCD may be insufficient due to limited knowledge of etiopathogenesis. Therefore, it is important to find inexpensive and easily determined biochemical parameters related to etiopathogenesis. In this study, the relationship between OCD and vitamin B12 (VitB12), folic acid (FA), vitamin D (VitD) and ferritin was investigated. Material and Method: 50 patients with OCD (12 female, 38 male) and 50 healthy controls (HC) (13 female, 37 male) were included in this retrospective study. Serum VitB12, FA, ferritin and 25-OH VitD levels of both groups were compared. Results: VitB12 (p <0.001), FA (p =0.004) and 25-(OH)VitD (p =0.001) serum levels were significantly lower in the OCD group than in the HC group. There was no significant difference between the two groups in terms of ferritin values. Conclusion: Our study shows that serum VitB12, FA and VitD deficiency can contribute to etiopathogenesis in OCD patients. This study may lead to research to find new pathways related to etiopathogenesis. For this, prospective studies with large participation are needed, including the post-treatment period. Amaç: Obsesif kompulsif bozukluk (OKB), obsesyon ve kompulsiyonlarla karakterize heterojen bir bozukluktur. Yapılan çalışmalara rağmen etyopatogenezi tam olarak anlaşılamamıştır. OKB'de farmakolojik ve psikososyal müdahaleler, sınırlı etyopatogenez bilgisi nedeniyle yetersiz olabilir. Bu nedenle etiyopatogenez ile ilgili ucuz ve kolay saptanabilen biyokimyasal parametrelerin bulunması önemlidir. Bu çalışmada OKB ile B12 vitamini (VitB12), folik asit (FA), D vitamini (VitD) ve ferritin ilişkisi araştırıldı. Gereç ve Yöntem: Bu retrospektif çalışmaya 50 OKB hastası (12 kadın, 38 erkek) ve 50 sağlıklı kontrol (SK) (13 kadın, 37 erkek) dahil edildi. Her iki grubun serum VitB12, FA, ferritin ve 25-OH VitD düzeyleri karşılaştırıldı. Bulgular: VitB12 (p <0.001), FA (p =0.004) ve VitD (p =0.001) serum düzeyleri OKB grubunda HC grubuna göre anlamlı olarak düşüktü. Ferritin değerleri açısından iki grup arasında anlamlı fark yoktu. Sonuç: Çalışmamız OKB hastalarında serum VitB12, FA ve VitD eksikliğinin etyopatogenez ile ilişkili olabileceğini göstermektedir. Bu çalışma, etiyopatogenez ile ilgili yeni araştırmalara öncülük edebilir. Bunun için tedavi sonrası dönemi de içeren geniş katılımlı prospektif çalışmalara ihtiyaç vardır. Anahtar Kelimeler: Obsesyon, B12 vitamini, folik asit, ferritin ve D vitamini

Periodontitis is a chronic inflammatory disease that destroys the bones and soft tissues that support the tooth as a result of inflammatory reactions. YKL-40 is an inflammatory marker associated with inflammation and is also associated with periodontal diseases. Moringa oleifera (MO) is a plant rich in high nutritional values, minerals, vitamins, and other essential phytochemicals. The aim of this study was to investigate the effect of MO administration on serum YKL-40 levels in an experimental periodontitis model. In the study, a total number of 24 female Wistar albino rats, which were 4–5 months old with a body weight of 275 ± 25 g, were used. Animals were divided into three groups. 1st group: Control (n = 8), 2nd group: periodontitis group (PG) (n = 8), 3rd group: Periodontitis group (PG + MO) with an additional 200 mg/kg/4 weeks MO (n = 8). In the PG and PG + MO were formed experimental periodontitis model. Compared to the PG, the decrease in the interleukin-6 (IL-6) and YKL-40 values in the PG + MO (p < 0.05, p < 0.05) was found to be significant in terms of statistical evaluation. As a result, MO decreased YKL-40 levels in the experimental periodontitis model. Although further research is needed, drugs containing MO can be used in the treatment of periodontal diseases.

Objective: Despite our understanding of Sertoli cell function and the state of spermatogenesis, the underlying mechanisms remain unclear. This study was conducted to compare the effects of orchiectomy and steroid treatment on fertility in testicular atrophy occurring after testicular torsion.Methods: Thirty-three rats were divided into four groups. The atrophy, orchiectomy, and atrophy-steroid groups each contained nine rats, while the control group contained six. The left testes were rotated 720º, and atrophy was observed. In the atrophy-steroid rats, orchiectomy was performed after atrophy, and 1 mg/kg steroid was injected. Each male rat was housed with five female rats for 6 days. The fertility of the male rats was evaluated based on the pregnancy of the female rats. Left and right orchiectomies were performed to determine the tissue Johnsen score (JS) and the serum inhibin B (IB) level.Results: JS values were significantly lower in the atrophy, orchiectomy, and atrophy-steroid groups than in the control group (p<0.05), while no significant difference was observed in JS between the atrophy and orchiectomy groups (p>0.05). Similarly, no significant differences in IB level or fertility percentage were found between the atrophy and orchiectomy rats (p>0.05).Conclusion: In unilateral testicular atrophy, which can occur in the prepubertal period due to various causes, orchiectomy does not appear to benefit fertility, as indicated by IB, JS, and the fertility percentage.