This study examines the trends and interannual variability of extreme precipitation in Antarctica, using six decades (1963–2023) of daily precipitation data from Russia’s Novolazarevskaya Station in East Antarctica. The results reveal declining trends in both the annual number of extreme precipitation days and the total amount of extreme precipitation, as well as a decreasing ratio of extreme to total annual precipitation. These trends are linked to changes in northward water vapor flux and enhanced downward atmospheric motion. The synoptic pattern driving extreme precipitation events is characterized by a dipole of negative and positive height anomalies to the west and east of the station, respectively, which directs southward water vapor flux into the region. Interannual variability in extreme precipitation days shows a significant correlation with the Niño 3.4 index during the austral winter semester (May–October). This relationship, weak before 1992, strengthened significantly afterward due to shifting wave patterns induced by tropical Pacific sea surface temperature anomalies. These findings shed light on how large-scale atmospheric circulation and tropical-extratropical teleconnections shape Antarctic precipitation patterns, with potential implications for ice sheet stability and regional climate variability.