The adsorption deposition of palladium hexafluoroacetylacetonate Pd(hfa)₂ on porous supports (γ-Al₂O₃ and hypercrosslinked polystyrene, HCP) in supercritical CO₂ is considered. The conditions for a transition of the Pd(hfa)₂/CO₂ system to a monophase region have been studied. Due to its reasonably high solubility in CO₂, the palladium compound can be deposited at relatively low pressures (~8.5 MPa) in the system. The adsorption of Pd(hfa)₂ on the given supports is well described by the Langmuir equation. An increase in the pressure in the system under isothermal conditions negatively affects the amount of adsorbed precursor because of the adsorption of CO₂ and distribution offset in the system. The limiting adsorption increases at elevated temperatures in the system under isochoric conditions.

The effect of the pressure and concentration of a micronized substance in a solution on the size and morphology of levofloxacin hydrochloride particles obtained using supercritical antisolvent (SAS) precipitation is investigated. It is shown that the crystallization of levofloxacin from the two-phase CO₂–acetone–levofloxacin system leads to the production of particles with a bimodal size distribution. An increase in pressure leads to a change in the precipitation regime, and as a result, the crystallization of smaller particles. Vapour–liquid equilibrium curves are obtained for the CO₂–acetone–levofloxacin hydrochloride system at a temperature of 40°C.

The effect of the solvent and the concentration of the micronized substance in the solution on the size and morphology of adipic acid (AA) particles precipitated by supercritical antisolvent precipitation (SAS) is investigated. An increase of the concentration of the micronized substance in the solution leads to a decrease in the particle size of AA and a narrowing of the particle size distribution. Depending on the solvent used and the concentration of AA in the solution, it is possible to produce particles of various morphologies ranging in size from tens to hundreds of microns via SAS.

It is shown that the yield of micronization products in a supercritical antisolvent (SAS) precipitation can be used for a qualitative assessment of the solubility of substances in CO₂–solvent mixtures. Assumptions for this approach are considered and recommendations are made to increase the accuracy of the assessment using this approach. The effect of the degree of supersaturation of the CO₂–solvent–substance being micronized system on the morphology and size of particles of malonic and succinic acids micronized by the SAS method is studied. The possibility of obtaining α-succinic acid by the SAS method is demonstrated.