To address the issue of inconsistencies between the 3D structural models built on Building Information Modeling (BIM) platforms and the original structural designs, thereby ensuring structural safety and reliability, this paper proposes an integrated design approach for prefabricated steel frame structures based on BIM technology with a primary focus on structural safety. The application of the integrated design methodology for prefabricated steel frame structures, leveraging BIM technology, is concretely demonstrated through case studies. These illustrations focus on pivotal aspects: assessing the overall safety performance of the structure, conducting meticulous analyses of beam-to-column connection nodes, and harnessing the outcomes of these evaluations to inform and direct the optimization of the structural design. The research findings presented herein offer insights and methodologies for applying BIM in safety assessments of prefabricated steel frame structures, thereby further refining the comprehensive framework of BIM engagement throughout the entire life cycle of prefabricated steel frame construction projects.