Artificial Intelligence (AI) is reshaping healthcare through advancements in clinical decision support and diagnostic capabilities. While human expertise remains foundational to medical practice, AI-powered tools are increasingly matching or exceeding specialist-level performance across multiple domains, paving the way for a new era of democratized healthcare access. These systems promise to reduce disparities in care delivery across demographic, racial, and socioeconomic boundaries by providing high-quality diagnostic support at scale. As a result, advanced healthcare services can be affordable to all populations, irrespective of demographics, race, or socioeconomic background. The democratization of such AI tools can reduce the cost of care, optimize resource allocation, and improve the quality of care. In contrast to humans, AI can potentially uncover complex relationships in the data from a large set of inputs and generate new evidence-based knowledge in medicine. However, integrating AI into healthcare raises several ethical and philosophical concerns, such as bias, transparency, autonomy, responsibility, and accountability. In this study, we examine recent advances in AI-enabled medical image analysis, current regulatory frameworks, and emerging best practices for clinical integration. We analyze both technical and ethical challenges inherent in deploying AI systems across healthcare institutions, with particular attention to data privacy, algorithmic fairness, and system transparency. Furthermore, we propose practical solutions to address key challenges, including data scarcity, racial bias in training datasets, limited model interpretability, and systematic algorithmic biases. Finally, we outline a conceptual algorithm for responsible AI implementations and identify promising future research and development directions.

Colonoscopy video acquisition has been tremendously increased for retrospective analysis, comprehensive inspection, and detection of polyps to diagnose colorectal cancer (CRC). However, extracting meaningful clinical information from colonoscopy videos requires an enormous amount of reviewing time, which burdens the surgeons considerably. To reduce the manual efforts, we propose a first end-to-end automated multi-stage deep learning framework to extract an adequate number of clinically significant frames, i.e., keyframes from colonoscopy videos. The proposed framework comprises multiple stages that employ different deep learning models to select keyframes, which are high-quality, non-redundant polyp frames capturing multi-views of polyps. In one of the stages of our framework, we also propose a novel multi-scale attention-based model, YcOLOn, for polyp localization, which generates ROI and prediction scores crucial for obtaining keyframes. We further designed a GUI application to navigate through different stages. Extensive evaluation in real-world scenarios involving patient-wise and cross-dataset validations shows the efficacy of the proposed approach. The framework removes 96.3% and 94.02% frames, reduces detection processing time by 38.28% and 59.99%, and increases mAP by 2% and 5% on the SUN database and the CVC-VideoClinicDB, respectively. The source code is available at https://github.com/Vanshali/KeyframeExtraction Note to Practitioners —The widespread acceptance of colonoscopy procedures as a gold standard for CRC screening is constrained by the massive amount of data recorded during the process that needs to be manually reviewed. Such manual procedures are burdensome and induce human diagnostic errors. This article suggests an automated framework to extract keyframes (important frames) from colonoscopy videos that can efficiently represent the clinically relevant information captured in the video streams. This is achieved by the automated removal of uninformative and highly correlated frames, which do not add to clinical findings. The approach ensures diversity among keyframes and provides clinicians with a multi-view of polyps for easy resection. In addition, the proposed multi-scale attention-based model improves the polyp localization performance, which further helps in refining the keyframe selection process. The comprehensive experimental results corroborate that discarding insignificant frames can enhance polyp detection and localization performance and reduce computational requirements. The study estimates 30% to 60% time saving for clinicians during video screening. In clinical practices, the proposed automated framework and our designed GUI would enable surgeons to visualize the essential data better with minimal manual interventions and assist in precise polyp resection.

Colorectal cancer (CRC) is marked by the development of tumors/outgrowths known as polyps. AI-assisted endoscopy is inevitable in the modern world for better and more efficient polyp detection and classification. Often, the risk associated with CRC is indicated by the polyp’s size. Automated size classification of colorectal polyps from endoscopic images is a boon to endoscopists to monitor and diagnose the polyps. While previous research efforts have predominantly centered around the pathological categorization of polyps, limited attention has been directed towards the classification of polyp size. In this paper, we have proposed a deep learning-based model for the multi-class classification of colorectal polyps into four classes: 0-5 mm, 5-10 mm, 10-14 mm, and >=14 mm. A narrow range in polyp size classification provides more information about the growth of the polyp as opposed to binary classification. We also show that the One vs Rest classification technique using binary classifiers outperforms the usual approach of using a single CNN for multi-class classification. Also, we use XGBoost with the binary classifiers to further increase the performance of the model. The experimental results report the effectiveness of our proposed model in performing multi-class polyp size classification. The approach is expected to assist clinicians in estimating polyp size efficiently.