Fibroin, a protein extracted from silk, offers advantageous properties such as non-immunogenicity, biocompatibility, and ease of surface modification, which have been widely utilized for a variety of biomedical applications. However, in vivo studies have revealed critical challenges, including rapid enzymatic degradation and limited stability. To widen the scope of this natural biomacromolecule, the grafting of polymers onto the protein surface has been advanced as a platform to enhance protein stability and develop smart conjugates. This review article brings into focus applications of fibroin-hybrid systems prepared using chemical modification of the protein with polymers and inorganic compounds. A selection of recent preclinical evaluations of these hybrids is included to highlight the significance of this approach.

Traditional biomaterials like CoCrMo, Ti, and stainless-steel face challenges due to their instability in biological settings. As an alternative, exploring multicomponent alloys is viewed as a viable path for bettering both mechanical performance and biocompatibility. Our research explores the potentiality of the MoNbNiTiZr based alloy for biomedical applications. The microstructural characterization was realized using X-Ray Diffractometry (XRD) and Scanning Electron Microscopy (SEM/EDS). We also conducted Vickers microhardness tests and assessed it’s in vitro biocompatibility and antibacterial action against S. aureus and S. aureus HU25 strains relative to cp-Ti. Our observations denote that this alloy showcases a triphasic structure, consisting of dendritic and interdendritic zones with BCC, HCP, and Laves formations. A microhardness of is approximately 576.5 HV align with values for comparable multicomponent alloys in the biomedical field. Pertaining to its antibacterial efficiency and in vitro compatibility, this alloy manifests commendable antibacterial performance and relevant compatibility in comparison with cp-Ti.