Polycystic ovary syndrome (PCOS) is a disorder with an unknown etiology that features a wide range of endocrine and metabolic abnormalities that hamper fertility. PCOS women experience difficulties getting pregnant, and if pregnant, they are prone to miscarriage, gestational diabetes, pregnancy-induced hypertension and preeclampsia, high fetal morbidity, and perinatal mortality. Insulin, the pancreatic hormone best known for its important role in glucose metabolism, has an underrated position in reproduction. PCOS women who have associated insulin resistance (with consequent hyperinsulinemia) have fertility issues and adverse pregnancy outcomes. Lowering the endogen insulin levels and insulin resistance appears to be a target to improve fertility and pregnancy outcomes in those women. Berberine is an alkaloid with a high concentration in various medicinal herbs that exhibits a hypoglycaemic effect alongside a broad range of other therapeutic activities. Its medical benefits may stand up for treating different conditions, including diabetes mellitus. So far, a small number of pharmacological/clinical trials available in the English language draw attention towards the good results of berberine’s use in PCOS women with insulin resistance for improving fertility and pregnancy outcomes. Our study aims to uncover how berberine can counteract the negative effect of insulin resistance in PCOS women and improve fertility and pregnancy outcomes.

Endometriosis is a non-malignant, inflammatory condition that impacts individuals across various hormonal stages, including before their first menstruation, throughout their reproductive years, and after menopause. This condition arises when tissue resembling the uterine lining grows outside the uterus, resulting in inflammation and a range of symptoms, such as dysmenorrhea, pain during intercourse, chronic discomfort, and challenges with fertility. This review provides a comprehensive analysis of the medical strategies implemented to address the pathology of endometriosis, highlighting its significant impact on the quality of life of the individuals affected by this condition. Endometriosis can influence various aspects of life, including physical health, emotional well-being, social interactions, and professional performance. Usually, to assess the quality of life in women with endometriosis, validated instruments, such as different questionnaire types, are used to measure the physical, psychological, social, and reproductive health impacts. To improve the quality of life of the women experiencing endometriosis, several supportive strategies are proposed. The findings underscore the necessity of managing endometriosis through a multidisciplinary approach that encompasses both medical and surgical interventions, lifestyle modifications, and psychological support.