Efstathios Konstantinou

Dr. Efstathios Konstantinou

orcid

Research Focus & Metrics

Academic Career Length

10Years (2017-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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7 July 2025 in Knee Surgery, Sports Traumatology, Arthroscopy
Verified
Journal Article
Open access
MKMahmut Enes Kayaalp
Mahmut Enes Kayaalp
EKEfstathios Konstantinou
Efstathios Konstantinou
BKBedri Karaismailoglu
Bedri Karaismailoglu
GLGian Andrea Lucidi
Gian Andrea Lucidi
MKMehmet Kaymakoglu
Mehmet Kaymakoglu
MHMichael T. Hirschmann
Michael T. Hirschmann
Purpose: The metaverse and extended reality (XR), which includes augmented reality (AR), virtual reality (VR) and mixed reality (MR), are transforming orthopaedic surgery by enhancing training, procedural accuracy and rehabilitation. However, a literature review of these new virtual tools is lacking. The purpose of this narrative review is to summarise available evidence about the metaverse and discuss current and future clinical applications.Methods: A narrative review of the current literature was performed for studies evaluating XR tools and their respective clinical and educational utility. Studies from all orthopaedic subspecialties were eligible for inclusion. The XR tools evaluated in each study were categorised according to the reality spectrum and future research or clinical applications were discussed.Results: XR is a technological spectrum that includes AR, VR and MR to create immersive and interactive surgical training environments. VR‐based simulators may improve surgical education by allowing trainees to refine their skills in a risk‐free setting. AR may enhance intraoperative guidance and has been studied within orthopaedics to improve implant positioning accuracy and reduce complications in procedures including arthroscopy and total joint arthroplasty. In rehabilitation, AR and VR have been implemented to facilitate patient engagement and adherence, promoting functional recovery through gamified therapy and remote telerehabilitation.Conclusions: There has been a paradigm shift in orthopaedic care in which digital tools are integrated with patient care to optimise patient outcomes. However, challenges to the widespread implementation of promising XR technology include high costs, steep learning curves and limited clinical validation. Ethical concerns, including data security and patient privacy, further complicate its use in clinical settings. Future research must focus on cost‐effectiveness, standardisation and improving accessibility to ensure seamless integration into clinical practice.Level of Evidence: Level V.

14 November 2024 in Journal of Joint Surgery and Research
Verified
Journal Article
Open access
KNKoji Nukuto
Koji Nukuto
EKEfstathios Konstantinou
Efstathios Konstantinou
AWAnja Maximiliane Wackerle
Anja Maximiliane Wackerle
JLJaren C. Lagreca
Jaren C. Lagreca
CGCamila Grandberg
Camila Grandberg
VMVolker Musahl
Volker Musahl

28 January 2024 in European Journal of Internal Medicine
Verified
Journal Article
Closed access
Antonios KoutalosAntonios Koutalos
Antonios Koutalos
AKAlexandros Koskiniotis
Alexandros Koskiniotis
CRChristos Rountas
Christos Rountas
EKEfstathios Konstantinou
Efstathios Konstantinou
SGSarah Georgiadou
Sarah Georgiadou
KMKonstantinos Malizos
Konstantinos Malizos

8 January 2025 in Journal of Clinical Medicine
Verified
Journal Article
Open access
PDF file
EKEfstathios Konstantinou
Efstathios Konstantinou
TPThomas Pfeiffer
Thomas Pfeiffer
MRMichael Scott Rocca
Michael Scott Rocca
CGCamila Grandberg
Camila Grandberg
KDKarina Dias
Karina Dias
VMVolker Musahl
Volker Musahl
Background: Postoperative infection following anterior cruciate ligament reconstruction (ACLR) is a rare yet severe complication that can compromise patient outcomes, leading to prolonged recovery, graft failure, and knee dysfunction. Although infection rates are reported to be less than 2%, it remains essential to implement strategies to reduce infection risk and improve surgical outcomes. Methods: This review explores current evidence on the prevention of infections in ACLR, emphasizing the importance of timely antibiotic prophylaxis and vancomycin presoaking of grafts, which has been associated with a substantial reduction in infection rates. Results: Empirical antibiotic therapy should be started immediately after joint aspiration when infection is suspected. Treatment must prioritize culture-specific antibiotic regimens to optimize patient outcomes. Surgical intervention with arthroscopic debridement and irrigation needs to occur as soon as the diagnosis of infection is made. Often, this is performed with a focus on retaining the graft in order to preserve knee stability, if possible. Careful intraoperative management, along with the aid of infectious disease specialists, is paramount to help optimize outcomes following infection after ACLR. Conclusions: This review emphasizes the need for treatment protocols and highlights areas for future research to establish clear guidelines on infection after ACLR, especially with decisions of graft retention versus removal.

13 July 2025 in Knee Surgery, Sports Traumatology, Arthroscopy
Verified
Journal Article
Closed access
EKEfstathios Konstantinou
Efstathios Konstantinou
ENEhab M. Nazzal
Ehab M. Nazzal
JHJonathan D. Hughes
Jonathan D. Hughes
BLBryson P. Lesniak
Bryson P. Lesniak
SRStephen J. Rabuck
Stephen J. Rabuck
VMVolker Musahl
Volker Musahl

3 February 2025 in Journal of ISAKOS
Verified
Journal Article
Open access
JGJoseph D Giusto
Joseph D Giusto
EKEfstathios Konstantinou
Efstathios Konstantinou
SRStephen J Rabuck
Stephen J Rabuck
BLBryson P Lesniak
Bryson P Lesniak
JHJonathan D Hughes
Jonathan D Hughes
PGPanther ACL Treatment Group
Panther ACL Treatment Group
This study aimed to determine the trends and indications for anterolateral complex augmentation during anterior cruciate ligament reconstruction (ACL-R) among international orthopedic sports surgeons. An electronically distributed survey was sent out to international surgeons with high-volume experience in complex ligament reconstructions and revision surgery attending the 2024 Freddie Fu Panther Sports Medicine Symposium. The survey was sent prior to the meeting with questions related to the use of lateral extra-articular tenodesis (LET) or anterolateral ligament reconstruction (ALL-R) during ACL-R. Sessions pertaining to anterolateral complex augmentation were held during the symposium to inform about current clinical practices among attendees. A total of 49 surgeons were identified from 5 different geographic regions prior to the meeting date and were sent an electronic survey, of which 48 responded (98% response rate). Among the surgeons who reported performing anterolateral complex augmentation procedures (n = 45), a total of 39 (87%) respondents reported using only the LET technique, 2 (4%) reported using only the ALL-R technique, and 4 (9%) reported using both techniques during ACL-R. The most common indication for anterolateral complex augmentation was a high-grade pivot shift, which 39 of 43 (91%) respondents ranked in their top 3 indications. In the setting of primary ACL-R, respondents added LET when using hamstring tendon autograft in 38% of cases on average compared with 34% of cases when using either bone-patellar tendon-bone autograft or quadriceps tendon autograft. In the setting of revision ACL-R, LET was added in an average of 68% of cases for a first-time revision ACL-R and in 84% of cases for a multiple-revision ACL-R. The most common indication for ACL-R with anterolateral complex augmentation was a high-grade pivot shift and most respondents preferred LET over ALL-R. Respondents performed LET in a comparable percentage of cases of primary ACL-R using hamstring tendon, bone-patellar tendon-bone, and quadriceps tendon autografts, and this number increased with the number of revision ACL-Rs. Based on the results of this survey, surgeons may consider adding LET in cases of revision ACL-R or in patients with a high-grade pivot shift. Level V.