This research delves into the co-pyrolysis of refuse-derived fuel (RDF) and oil shale (OS), utilizing a 50% weight ratio for each component. The study employs a fixed-bed reactor, augmented by electrical kiln heating, to conduct the co-pyrolysis process. A significant aspect of this research is the use of Aspen Plus software for process simulation, with the simulated results undergoing validation through experimental data. A commendable correlation was observed between the experimental outcomes and the model predictions, underscoring the reliability of the simulation approach. The investigation reveals distinct product yields from the pyrolysis of 100% RDF and 100% OS. Specifically, the pyrolysis of pure RDF yielded 45.26% gas, 20.67% oil, and 34.07% char by weight. In contrast, the pyrolysis of pure OS resulted in 14.51% gas, 8.32% liquid, and a significant 77.61% char by weight. The co-pyrolysis of RDF and OS in a 50% blend altered the product distribution to 31.98% gas, 12.58% liquid, and 55.09% char by weight. Furthermore, the Aspen Plus simulation model aligned closely with these findings, predicting yields of 31.40% gas, 11.9% oil, and 56.6% char by weight for the RDF-OS blend. This study not only elucidates the co-pyrolysis behavior of RDF and OS but also contributes valuable insights into the potential of these materials to address the pressing issue of plastic waste management and energy resource utilization. The findings underscore the efficacy of RDF and OS co-pyrolysis as a viable strategy for enhancing the value extraction from waste and underutilized energy resources, presenting a promising avenue for environmental and energy sustainability.