Cardiac tumors (CTs), although rare, can be a significant cause of sudden cardiac death (SCD), particularly when not diagnosed early. The tumors most associated with SCD include myxomas, fibromas, rhabdomyomas, and sarcomas, which can cause fatal arrhythmias, blood flow obstruction, or embolization. Myxomas, which often develop in the left atrium, can cause valvular obstruction or cerebral emboli, while malignant tumors, such as sarcomas, can infiltrate the myocardium or conduction system, causing serious arrhythmias. Rhabdomyomas, which are common in children and associated with tuberous sclerosis, can lead to ventricular tachyarrhythmias. Early diagnosis using advanced imaging techniques such as echocardiography and magnetic resonance imaging is crucial for preventing SCD. Timely diagnosis and precise characterization of lesions can help reduce the risk of SCD, thus improving the clinical management of patients, with the aim of supporting personalized treatment and improving life prospects. In this state-of-the-art review, we analyze the association between CTs and SCD, with particular attention to the histological features of benign and malignant neoplasms. Through an updated overview of the pathological aspects, we aim to improve the understanding of these tumors and promote a more effective multidisciplinary diagnostic and therapeutic approach to prevent fatal events.

Even though children’s malignant bone tumours are rare, it is crucial to understand how to identify and stage them accurately to develop an appropriate treatment plan. Ewing’s sarcoma and osteosarcoma are the two main paediatric bone malignancies and require multidisciplinary treatment involving radiologists, orthopaedists, oncologists, pathologists, and paediatricians. These neoplasms may be associated with genetic syndromes but typically occur in patients with no known germline abnormalities. With a frequency of 4.4 per million, osteosarcoma is the most common malignant bone tumour in children. Ewing’s sarcoma has an incidence of 2.5 to 3 per million, making it the second most prevalent. Clinically, these neoplasms present with pain and inflammation in the bones and joints, nocturnal pain unresponsive to drug therapy, systemic symptoms such as fever or weight loss, and persistent symptoms—all of which should prompt clinicians to initiate further diagnostic investigations. The gold standard for diagnosis includes X-ray examination and MRI, which provide an accurate assessment of tumour extension into the medullary canal and surrounding soft tissues. Fluorine-18-labelled FDG-PET scans or fluoro-deoxyglucose positron emission tomography are valuable for evaluating tumour aggressiveness and excluding metastases. A biopsy is mandatory once all other diagnostic tests have been completed. Accurate diagnosis and timely referral to an experienced clinic are essential for ensuring prompt access to treatment and improving patient outcomes.

Primary Fallopian tube carcinomas (PFTCs) are rare malignancies that are often misclassified as ovarian cancers due to overlapping clinical and pathological features. This frequent misdiagnosis contributes to the under-recognition of PFTCs, which account for a larger proportion of pelvic malignancies than historically reported. The central aim of this literature review is to highlight the critical importance of and methods for achieving an early diagnosis of Fallopian tube cancer, to improve patient outcomes. We classify benign and malignant fallopian tube neoplasms and evaluate the essential role of clinical evaluation and advanced imaging techniques, considering especially ultrasound, MRI, and PET-CT, in achieving an accurate and timely diagnosis. While histopathology remains the gold standard, imaging is pivotal for differentiating benign from malignant tubal lesions. This review details clinical manifestations, diagnostic pitfalls, and the necessity of a multidisciplinary approach to management. We conclude that advancing early detection through refined diagnostic criteria is essential to guiding effective, patient-specific therapeutic interventions.

The application of advanced imaging techniques, particularly computed tomography (CT), photogrammetric scanning, and three-dimensional reconstructions of body surfaces and skeletal remains, is becoming a crucial component of Forensic Anthropology. These tools enable a non-invasive and highly standardized analysis of both intact cadavers and human remains recovered from terrestrial or aquatic environments, providing reliable support in identification processes, traumatological reconstruction, and the assessment of taphonomic processes. In the context of estimating the Post-Mortem Interval (PMI) and the Post-Mortem Submersion Interval (PMSI), digital imaging allows for the objective and reproducible documentation of morphological changes associated with decomposition, saponification, skeletonization, and taphonomic patterns specific to the recovery environment. Specifically, CT enables the precise assessment of gas accumulation, transformations in residual soft tissues, and structural bone modifications, while photogrammetry and 3D reconstructions facilitate the longitudinal monitoring of transformative processes in both terrestrial and underwater contexts. These observations enhance the reliability of PMI/PMSI estimates through integrated models that combine morphometric, taphonomic, and environmental data. Beyond PMI/PMSI estimation, imaging techniques play a central role in anthropological bioprofiling, facilitating the estimation of age, sex, and stature, the analysis of dental characteristics, and the evaluation of antemortem or perimortem trauma, including damage caused by terrestrial or fauna. Three-dimensional documentation also provides a permanent, shareable archive suitable for comparative analyses, ensuring transparency and reproducibility in investigations. Although not a complete substitute for traditional autopsy or anthropological examination, imaging serves as an essential complement, particularly in cases where the integrity of remains must be preserved or where environmental conditions hinder the direct handling of osteological material. Future directions include the development of AI-based predictive models for PMI/PMSI estimation using automated analysis of post-mortem changes, greater standardization of imaging protocols for aquatic remains, and the use of digital sensors and multimodal techniques to characterize microstructural alterations not detectable by the naked eye. The integration of high-resolution imaging and advanced analytical algorithms promises to further enhance the reconstructive accuracy and interpretative capacity of Forensic Anthropology.

Brain death, defined as the irreversible cessation of all brain functions, including the brainstem, is a critical concept in modern medicine, particularly in the context of organ transplantation. The diagnosis of brain death relies primarily on a thorough clinical neurological examination, which assesses the absence of brainstem reflexes, coma, and apnoea. This paper underscores the critical role of neuroimaging-based ancillary tests in enhancing the accuracy of brain death determination and calls for harmonization of protocols to address existing disparities and improve clinical practice worldwide. The use of ancillary tests, particularly neuroimaging techniques plays a crucial role in confirming the diagnosis, especially in cases where clinical examination is inconclusive or confounded by factors such as drug intoxication or hypothermia. These tests provide objective evidence of the absence of cerebral blood, thereby supporting the clinical determination of brain death. Despite global consensus on the importance of the clinical neurological examination in diagnosing brain death, significant variations exist between countries regarding the use of ancillary tests, the number of required clinical examinations, observation periods, and the number of physicians involved in the determination process. The discrepancies among international guidelines, highlight the need for standardized to ensure consistency and reliability in brain death diagnosis, particularly in the context of organ transplantation, where timely and accurate diagnosis is essential. This literature review examines brain death in the context of organ donation, highlighting the differences in diagnostic protocols worldwide. It emphasises the importance of clinical and neuroimaging tests for accurate diagnosis and the need to standardise international guidelines to improve clinical practice and ensure timely and reliable decisions, particularly in organ transplantation.

Background/Objectives: Establishing the identity of unknown individuals has always been one of the primary objectives of anthropologists and forensic pathologists in judicial contexts. Particularly when human remains are found in advanced stages of decomposition, carbonization, or fragmentation conditions that may compromise the efficacy of techniques such as DNA analysis or dental comparison innovative methodologies, including craniofacial superimposition, are employed, often supplemented by further examinations. This study presents the discovery of an individual in an advanced state of decomposition, transitioning from the colliquative to the semi-skeletal phase, demonstrating how degenerative processes can alter soft tissues to the extent of hindering genetic investigations. Methods: The multidisciplinary investigation conducted to resolve the case is described in two phases: the first, of an anthropological and medico-legal nature, aimed at reconstructing the biological profile (sex, age, stature, ancestry); the second, anthropological in focus, directed toward identification through craniofacial superimposition, applying two established methods from the literature the linear method and the computer-assisted comparison approach. Results: The results obtained from both investigative phases proved decisive, providing a significant and anticipated resolution for the authorities involved. Conclusions: This judicial case ultimately reaffirms the critical importance of multidisciplinary collaboration in forensic investigations.