Linda Knutsson

Prof. Linda Knutsson

orcid

Research Focus & Metrics

Academic Career Length

25Years (2002-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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22 April 2022 in Magnetic Resonance in Medicine
Verified
Journal Article
Open access
JZJinyuan Zhou
Jinyuan Zhou
MZMoritz Zaiss
Moritz Zaiss
LKLinda Knutsson
Linda Knutsson
PSPhillip Sun
Phillip Sun
SASung Soo Ahn
Sung Soo Ahn
PZPeter C. M. van Zijl
Peter C. M. van Zijl
Amide proton transfer‐weighted (APTw) MR imaging shows promise as a biomarker of brain tumor status. Currently used APTw MRI pulse sequences and protocols vary substantially among different institutes, and there are no agreed‐on standards in the imaging community. Therefore, the results acquired from different research centers are difficult to compare, which hampers uniform clinical application and interpretation. This paper reviews current clinical APTw imaging approaches and provides a rationale for optimized APTw brain tumor imaging at 3 T, including specific recommendations for pulse sequences, acquisition protocols, and data processing methods. We expect that these consensus recommendations will become the first broadly accepted guidelines for APTw imaging of brain tumors on 3 T MRI systems from different vendors. This will allow more medical centers to use the same or comparable APTw MRI techniques for the detection, characterization, and monitoring of brain tumors, enabling multi‐center trials in larger patient cohorts and, ultimately, routine clinical use.

4 December 2009 in Magnetic Resonance Materials in Physics, Biology and Medicine
Verified
Journal Article
Closed access
PDF file
LKLinda Knutsson
Linda Knutsson
FSFreddy Ståhlberg
Freddy Ståhlberg
RWRonnie Wirestam
Ronnie Wirestam

15 May 2020 in Science Advances
Verified
Journal Article
Open access
PDF file
JHJianpan Huang
Jianpan Huang
PZPeter C. M. van Zijl
Peter C. M. van Zijl
XHXiongqi Han
Xiongqi Han
CDCelia M. Dong
Celia M. Dong
GCGerald W. Y. Cheng
Gerald W. Y. Cheng
Kannie WY ChanKannie WY Chan
Kannie WY Chan
D -glucose–enhanced MRI detects altered CSF flow and glucose utilization in early Alzheimer’s disease when plaque formation begins.

7 May 2021 in Magnetic Resonance in Medicine
Verified
Journal Article
Open access
PDF file
KHKai Herz
Kai Herz
SMSebastian Mueller
Sebastian Mueller
Or PerlmanOr Perlman
Or Perlman
MZMaxim Zaitsev
Maxim Zaitsev
LKLinda Knutsson
Linda Knutsson
MZMoritz Zaiss
Moritz Zaiss
Purpose: As the field of CEST grows, various novel preparation periods using different parameters are being introduced. At the same time, large, multisite clinical studies require clearly defined protocols, especially across different vendors. Here, we propose a CEST definition standard using the open Pulseq format for a shareable, simple, and exact definition of CEST protocols.Methods: We present the benefits of such a standard in three ways: (1) an open database on GitHub, where fully defined, human‐readable CEST protocols can be shared; (2) an open‐source Bloch‐McConnell simulation to test and optimize CEST preparation periods in silico; and (3) a hybrid MR sequence that plays out the CEST preparation period and can be combined with any existing readout module.Results: The exact definition of the CEST preparation period, in combination with the flexible simulation, leads to a good match between simulations and measurements. The standard allowed finding consensus on three amide proton transfer–weighted protocols that could be compared in healthy subjects and a tumor patient. In addition, we could show coherent multisite results for a sophisticated CEST method, highlighting the benefits regarding protocol sharing and reproducibility.Conclusion: With Pulseq‐CEST, we provide a straightforward approach to standardize, share, simulate, and measure different CEST preparation schemes, which are inherently completely defined.

25 September 2007 in Journal of Magnetic Resonance Imaging
Verified
Journal Article
Open access
PDF file
LKLinda Knutsson
Linda Knutsson
SBSiv Börjesson
Siv Börjesson
ELElna‐Marie Larsson
Elna‐Marie Larsson
JRJarl Risberg
Jarl Risberg
LGLars Gustafson
Lars Gustafson
RWRonnie Wirestam
Ronnie Wirestam
Purpose: To compare absolute cerebral blood flow (CBF) estimates obtained by dynamic susceptibility contrast MRI (DSC‐MRI) and Xe‐133 SPECT.Materials and Methods: CBF was measured in 20 healthy volunteers using DSC‐MRI at 3T and Xe‐133 SPECT. DSC‐MRI was accomplished by gradient‐echo EPI and CBF was calculated using a time‐shift‐insensitive deconvolution algorithm and regional arterial input functions (AIFs). To improve the reproducibility of AIF registration the time integral was rescaled by use of a venous output function. In the Xe‐133 SPECT experiment, Xe‐133 gas was inhaled over 8 minutes and CBF was calculated using a biexponential analysis.Results: The average whole‐brain CBF estimates obtained by DSC‐MRI and Xe‐133 SPECT were 85 ± 23 mL/(min 100 g) and 40 ± 8 mL/(min 100 g), respectively (mean ± SD, n = 20). The linear CBF relationship between the two modalities showed a correlation coefficient of r = 0.76 and was described by the equation CBF(MRI) = 2.4 · CBF(Xe)−7.9 (CBF in units of mL/(min 100 g)).Conclusion: A reasonable positive linear correlation between MRI‐based and SPECT‐based CBF estimates was observed after AIF time‐integral correction. The use of DSC‐MRI typically results in overestimated absolute perfusion estimates and the present study indicates that this trend is further enhanced by the use of high magnetic field strength (3T). J. Magn. Reson. Imaging 2007;26:913–920.

1 August 2017 in NeuroImage
Verified
Journal Article
Closed access
ARAnna S. Rydhög
Anna S. Rydhög
FSFilip Szczepankiewicz
Filip Szczepankiewicz
RWRonnie Wirestam
Ronnie Wirestam
AAAndré Ahlgren
André Ahlgren
CWCarl-Fredrik Westin
Carl-Fredrik Westin
OPOfer Pasternak
Ofer Pasternak