The rapid diagnosis of respiratory virus infection through breath and blow remains challenging. Here we develop a wireless, battery-free, multifunctional pathogenic infection diagnosis system (PIDS) for diagnosing SARS-CoV-2 infection and symptom severity by blow and breath within 110 s and 350 s, respectively. The accuracies reach to 100% and 92% for evaluating the infection and symptom severity of 42 participants, respectively. PIDS realizes simultaneous gaseous sample collection, biomarker identification, abnormal physical signs recording and machine learning analysis. We transform PIDS into other miniaturized wearable or portable electronic platforms that may widen the diagnostic modes at home, outdoors and public places. Collectively, we demonstrate a general-purpose technology for rapidly diagnosing respiratory pathogenic infection by breath and blow, alleviating the technical bottleneck of saliva and nasopharyngeal secretions. PIDS may serve as a complementary diagnostic tool for other point-of-care techniques and guide the symptomatic treatment of viral infections.

Natural enzymes are crucial in biological systems and widely used in biomedicine, but their disadvantages, such as insufficient stability and high cost, have limited their widespread application. Since discovering the enzyme-like activity of Fe₃O₄ nanoparticles, extensive research progress in diverse nanozymes has been made with their in-depth investigation, resulting in rapid development of related nanotechnologies. Nanozymes can compensate for the defects of natural enzymes and show higher stability with lower costs. Among them, peroxidase (POD)-like nanozymes have attracted extensive attention in biomedical applications owing to their efficient catalytic performance and diverse structures. This review explores different types of nanozymes with POD-like activity and discusses their activity regulation, particularly emphasizing their latest development trends and advances in biosensing and disease treatment. Finally, the challenges and prospects for the development of POD-like nanozymes and their potential future applications in the biomedical field are also provided.

Nebulized inhalation is a non-invasive drug delivery method with fast onset, low dosage, and fewer side effects. This review covers its principles, devices, clinical applications, and future trends in respiratory and systemic diseases.

The ISFET is a label-free, miniaturized, sensitive, and rapid-response sensor for disease screening and monitoring. This review covers its structure, recent researches, challenges, solutions, and future prospects for biomarker measurement.