Objective: The aim of this study is to evaluate current urologic practice regarding the management of priapism in Turkey and compare with international guidelines. Methods: Urologists and urology residents were invited to an online survey consisting of 30 multiple-choice questions on priapism-related clinical practices that were consid- ered most important and relevant to practices by using Google Forms. Results: Total number of responses was 340. Respondents reported that they recorded a detailed patient’s medical history and physical examination findings (n = 340, 100%) and laboratory testing, which includes corporal blood gas analysis (n=323, 95%). Participants announced that they performed Doppler ultrasound for 1/4 cases (n = 106, 31%), but 22% of the participants (n=75) replied that they performed in >75% of cases. Participants (n=311, 91%) responded that the first-line treatment of ischemic priapism is decompression of the corpus cavernosum. Moreover, most respondents (n = 320, 94%) stated that sympathomimetic injection drugs should be applied as the second step. About three-quarters of respondents (n = 247, 73%) indicated adrenaline as their drug of choice. Phosphodiesterase type 5 inhibitors seems to be the most pre- ferred drug for stuttering priapism (n=141, 41%). Participants (n=284, 84%) replied that corpora-glanular shunts should be preferred as the first. A large number of par- ticipants (n = 239, 70%) declared that magnetic resonance imaging can be performed in cases with delayed (>24 hours) priapism to diagnose corporal necrosis. Most of the participants (84%) responded that penile prosthesis should be preferred to shunts in cases with delayed (>48 hours) priapism. Conclusion: It would be appropriate to improve the training offered by professional associations and to give more training time to the management of priapism during residency. Cite this article as: Kalkanli A, Zeki Sönmez S, Guvel M, et al. Management of priapism: Results of a nationwide survey and comparison with international guidelines. Urol Res Pract. 2023;49(4):225-232.
Objective: In this study, we aimed to investigate the antioxidant effects of selenium and coenzyme Q on renal damage in a partial unilateral ureteral obstruction (PUUO) in a rat model. Material and methods: A total of 24 Sprague-Dawley rats were divided into four groups as Group 1 Control Group, Group 2, PUUO Group, Group 3 PUUO + coenzyme Q group, Group 4 PUUO + selenium group. Paraoxonase (PON), total antioxidant capacity (TAC), and total oxidant levels (TOS) were analyzed biochemically from tissue and blood samples. Tissue samples were examined histopathologically. Results: The TAC in the tissues was found to be statistically significantly increased in Groups 3 and 4, compared to Group 2. Tissue TOS was found to be significantly reduced in Groups 3 and 4, compared to Group 2. Serum PON levels were significantly increased in Group 3 and 4, compared to Group 1 and 2. Histopathological examination showed that interstitial inflammation and congestion were lesser in the coenzyme Q and selenium groups than in the PUUO group. A more significant decrease was found in the selenium group than in the coenzyme Q group. Conclusion: Our study results showed that coenzyme Q and selenium reduced the oxidation and the damage in tissue in PUUO in rats. Cite this article as: Kırdağ MK, Tuğlu D, Yuvanç E, Kısa Ü, Balcı M, Batislam E, et al. The effect of coenzyme Q and selenium on kidney in rats with partial unilateral ureteral obstruction. Turk J Urol 2019; 45(Supp. 1): S70-S77.
Mesane Ağrısı Sendromu/İnterstisyel Sistit (MAS/İS), kronik pelvik ağrı sendromları içerisinde tanısal güçlükleri ve heterojen klinik özellikleri ile öne çıkan kompleks bir hastalıktır. Tanım ve terminolojideki değişikliklere rağmen günümüzde Uluslararası Kontinans Derneği, MAS/İS’i idrar yolu enfeksiyonu veya belirgin patoloji olmaksızın, mesanenin dolmasıyla ortaya çıkan suprapubik ağrı ve eşlik eden işeme semptomları ile karakterize bir tablo olarak tanımlamaktadır. Hastalığın etiyopatogenezi tam olarak açıklığa kavuşmamış olup; ürotelyal bariyer disfonksiyonu, otoimmün mekanizmalar, mast hücre aktivasyonu, antiproliferatif faktör üretimi ve nörojenik mekanizmalar gibi hipotezler öne sürülmektedir. Tanı süreci ayrıntılı öykü, semptom skorlamaları, fizik muayene, laboratuvar tetkikleri ve sistoskopi ile multidisipliner bir yaklaşımla gerçekleştirilmelidir. Tedavide temel amaç semptom kontrolü ve yaşam kalitesinin artırılmasıdır. Bu doğrultuda hasta bilgilendirmesi ve davranışsal düzenlemeler ilk basamağı oluştururken; farmakolojik tedaviler (ör. pentosan polisülfat, amitriptilin), intravezikal ajanlar, botulinum toksin uygulamaları ve nöromodülasyon daha ileri seçeneklerdir. Dirençli olgularda cerrahi tedavi gündeme gelebilmektedir. Güncel kılavuzlar, fenotip temelli ve bireyselleştirilmiş tedavi yaklaşımlarının önemini vurgulamaktadır.
Introduction: Accurate assessment of kidney stone burden is essential for clinical decision-making. This study aimed to evaluate the efficacy of “InVesalius,” an open-source 3D imaging software, for stone volume measurement and compare its performance with 3D Slicer software and the traditional ellipsoid formula. Methods: In this prospective study, 65 patients with kidney stones confirmed by non-contrast enhanced computed tomography were enrolled between January and April 2025. Stone volumes were calculated using “InVesalius,” “3D Slicer” (Kidney Stone Calculator extension), and the ellipsoid formula. Correlations between methods were assessed with Spearman’s rank-order correlation. Results: “InVesalius” and “3D Slicer” showed highly comparable results ( r = 0.99, p < 0.001), both consistently yielding slightly larger volumes than the ellipsoid formula. All methods demonstrated strong correlations, though discrepancies were most evident between the ellipsoid formula and the 3D-based methods. Conclusions: “InVesalius” provides reliable kidney stone volume measurements comparable to 3D Slicer and superior to the ellipsoid formula. Its free availability, DICOM compatibility, and ease of use make it particularly valuable in clinical and research environments lacking access to commercial imaging tools.